It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, we study the effect of IL-2 stimulation on NK cell inhibitory receptors Ly49A, Ly49C, and activating receptor Ly49D in C57BL/6 mice.

Aug 8, 2018 · In addition to its initially recognized role in T cell proliferation, IL-2 was shown to potently boost the cytolytic activity of NK cells 15 and lymphokine-activated killer cells 16....

Recent data have provided evidence that IL-2 and IL-15 differ in their ability to activate T and NK cells to resist various forms of immune suppression. The diverse roles of these two cytokines have on immune cells lead to critical therapeutic implications for cancer treatment.

Low‐dose interleukin (IL)‐2 has shown clinical benefits in patients with autoimmune and inflammatory diseases. Both regulatory T cells (T regs) and natural killer (NK) cells are increased in response to low‐dose IL‐2 immunotherapy.

This review examines the pervasive effects of IL-2 and IL-15 on NK cell biology, with an emphasis on recent discoveries and lingering challenges in the field. Natural killer (NK) cells are CD56+CD3- large granular lymphocytes that constitute a key component of the human innate immune response.

May 15, 2000 · In addition to IL-12, NK cells are responsive to IL-2, and may mediate some of the antitumor effects of IL-2. In this study, we examine the interaction between IL-2 and the signaling events induced by IL-12 in NK cells.

Sep 22, 2022 · To improve the persistence of NK cells and attenuate the systemic toxicity of IL-2, we constructed a cell-restricted artificial IL-2, named membrane-bound IL-2 (mbIL-2), comprising human IL-2 and human IL-2Rα joined by a classic linker.

Dec 19, 2017 · Here, we study the effect of IL-2 stimulation on NK cell inhibitory receptors Ly49A, Ly49C, and activating receptor Ly49D in C57BL/6 mice. It was observed that there was significant increase in expression of Ly49A but no change in expression of Ly49C and …

Jun 15, 2000 · Using freshly isolated human NK cells, we established that an intact MKK/ERK pathway is necessary for IL-2 to activate NK cells to express at least four known biological responses: LAK generation, IFN-γ secretion, and CD25 and CD69 expression.

Jan 1, 1999 · To explore alternative pathways for IL-2 signaling in NK cells, we examined the activation of different STATs in response to IL-2 in two human NK cell lines, NKL and NK3.3. Both of these cell lines are IL-2 responsive and require IL-2 to maintain growth in vitro.