The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …

Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell …

Feb 22, 2021 · We found that both IL-2 and IL-4 must be present in culture together to manifest the synergistic IL-10 response (Figure 1H and Figure 1—figure supplement 2C), implicating …

Aug 8, 2018 · IL-2 has been shown to induce STAT5-mediated IL-4Rα expression, priming cells for T H 2 differentiation, as well as to induce epigenetic changes at the Il4 locus, promoting T …

Low dose of antigen stimulation may result in IL-2-dependent STAT5-driven early IL-4 production, which in turn further promotes Th2 cell differentiation 40. Both IL-2- and IL-4-mediated …

After IL-4 binding IL-4Rα, the IL-4 receptor is created by dimerization with the common γ chain (γc) to create the type 1 signaling complex or with IL-13Rα1 to create the type 2 complex. Both …

Apr 1, 2023 · The interleukin-2 (IL-2) family cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which share γ chain (γc) subunit in receptors. The IL-2 family cytokines have unique …

Sep 25, 2024 · Here we show that an interleukin-4 fusion protein (Fc–IL-4), a typical type 2 cytokine, directly acts on CD8+ T cells and enriches functional terminally exhausted CD8+ T …

Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a 15.5–16 kDa protein [5] that regulates the activities of white blood …

Feb 22, 2021 · Here, we found that regulatory T cells (Tregs) integrate concurrent signaling initiated by IL-2 and IL-4 to generate a response divergent from the sum of the two pathways …