Jan 11, 2021 · This study reveals a double-edged role for IL-2 in regulating tumor-specific CD8 + T cells. IL-2 can promote CD8 + T cell activation and proliferation at an early tumor stage, but can switch...

Jul 1, 2024 · We demonstrate that toxicity can be decoupled from antitumor activity in preclinical models by limiting IL2 signaling to CD8+ T cells, supporting the development of CD8+ T cell-selective IL2 for the treatment of cancer.

Here, we show that interleukin-2 (IL-2) acts as an environmental cue to induce CD8 + T cell exhaustion within tumor microenvironments.

Feb 11, 2022 · Here, we show that the capacity to manufacture IL-2 identifies constituents of the expanded CD8 T cell effector pool that display stem-like features, preferentially survive, rapidly attain memory traits, resist exhaustion, and control chronic viral challenges.

During the secondary priming phase, CD8 T cells received IL-2 signals, indicated by increased phosphorylation of STAT5 (signal transducer and activator of transcription 5). Although CD8 T cells formed stable interactions with DCs during this time, CD4 T helper cells showed a different migratory behavior and only interacted with DC for a few ...

Sep 11, 2024 · Paracrine IL-2 signalling drives the CD8 + T cell expansion and differentiation that allow protection against viral infections, but the underlying molecular events are incompletely understood.

Sep 15, 2021 · Here we show that H9T, an engineered interleukin-2 partial agonist, promotes the expansion of CD8 + T cells without driving terminal differentiation. H9T led to altered STAT5 signalling and...

5 days ago · CXCR3 expression by CD8 T cells was required for their hours-long reengagement with DCs in specific subfollicular niches in lymph nodes. CD4 T cells paused briefly at the sites of CD8 T cell and DC interactions and provided Interleukin-2 (IL-2) before moving to another DC. Our results highlight a previously unappreciated phase of cell-cell ...

Mar 14, 2025 · SSC-A, side scatter area; PE-TR, phycoerythrin–Texas red. (H) Quantification of IL-2 + cells and IL-2 MFI among OT-1 CD8 + T cells stimulated for the indicated times with N4 Ova peptide. (I) Representative staining for IFN-γ and TNF-α in OT-1 CD8 + T cells of the indicated genotypes stimulated for 24 hours with N4 Ova peptide or T4 ...

IL-2 induces the SUMOylation of AHR in CD8 + T cells, protecting it from degradation by ubiquitination. These findings have deep implications for cancer immunotherapy. First, targeting IL-2 is a good therapeutic approach for advanced tumors. This could be achieved by the neutralization of IL-2, blockade of IL-2 receptors, or depletion of IL-2 ...