Neutralization of IL-1β attenuated the microglia activation, prevented the loss of PV+ interneurons and normalized dopaminergic fiber density in the globus pallidus of brain-injured animals. These findings argue for an important role for neuro-inflammation in …

Dec 10, 2019 · These studies show that IL-1β overexpression early in amyloid pathogenesis induces a change in the microglial gene expression profile and an expansion of microglial cells that facilitates Aβ plaque clearance. Neuroinflammation has long been recognized as a key component in Alzheimer’s disease (AD) pathogenesis.

Here, we show that PDGFB -driven GBM cells induce the expression of the potent proinflammatory cytokine IL-1β in MDM, which engages IL-1R1 in tumor cells, activates the NF-κB pathway, and subsequently leads to induction of monocyte chemoattractant proteins (MCPs).

Nov 25, 2021 · These results indicated that inflammatory cytokines (TNFα, IL-1β, and IL-6) were induced at 6–12 h in advance of the upregulation of Iba1 and GFAP levels by microglia/astrocytes as well as infiltrated monocytes/macrophages, which occurred at 24 h …

IL-1β is a pivotal proinflammatory cytokine involved in the regulation of the hosts’ innate immune response. Intrinsically IL-1β-mediated inflammation has evolved to combat microbes and aid in tissue repair mechanisms (Dinarello 2011).

Jun 6, 2019 · IL1β failed to provide neuroprotection in the IL-1R1-null retina, but IL1β-mediated neuroprotection was rescued when expression of IL-1R1 was restored in astrocytes. We conclude that reactive microglia provide protection to retinal neurons, since the absence of microglia is detrimental to survival.

Oct 30, 2019 · We demonstrated a reduction in blood–brain barrier integrity and oedema formation, respectively, when either IL-1R1, IL-1β, or both IL-1α and IL-1β were homozygous lost compared to wild-type tumour-bearing mice.

Jun 5, 2020 · In the present study, we determined the cellular expression of IL-1α, IL-1β, IL-1Ra, TNF, TNFR1, and TNFR2 in post-mortem ischemic brain tissue and, in parallel, the expression of the microglial/macrophage markers CD68, CD45 and Iba1 and the astrocytic marker glial fibrillary acidic protein (GFAP).

Sep 21, 2023 · Here, we show that PDGFB -driven GBM cells induce the expression of the potent proinflammatory cytokine IL-1β in MDM, which engages IL-1R1 in tumor cells, activates the NF-κB pathway, and subsequently leads to induction of monocyte chemoattractant proteins (MCPs).

Apr 24, 2017 · Here, we explore the role of interleukin-1β (IL-1β) in modulating AMD-associated chemokines Ccl2, Cxcl1, and Cxcl10 during photo-oxidative retinal damage, and the effect on both the accumulation of outer-retinal macrophages, and death of photoreceptors.