Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1. [1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding. [ 1 ]

This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses.

The family of IL-1 receptors (IL-1R) includes 10 structurally related members, and the distantly related soluble protein IL-18BP that acts as inhibitor of the cytokine IL-18. Over the years the receptors of the IL-1 family have been known with many different names, with …

IL-1ra is an important regulator of IL-1-induced expression and physiological responses elicited by IL-1. IL-1ra functions as a competitive inhibitor of IL-1 receptor in vivo and in vitro. It counteracts the effects of both IL-1α and IL-1β. Upon binding of IL-1ra, the IL-1 receptor does not transmit a signal to the cell.

Each member of the IL-1 receptor and TLR family contains the cytoplasmic Toll-IL-1-Receptor (TIR) domain. The 50 amino acid TIR domains are highly homologous with the Toll protein in Drosophila. The TIR domain is nearly the same and present …

IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1 in a number of human autoinflammatory diseases.

The IL-1 receptor (IL-1R) is a member of the immunoglobulin superfamily. There are two subtypes of IL-1R. Subtype 1 (IL-1RI) binds IL-1α preferentially and is found on T cells, endothelial cells, keratinocytes, hepatocytes, and fibroblasts.

Sep 12, 2019 · IL-1 family members are categorized into three subfamilies on the basis of shared receptor or co-receptor binding: IL-1α, IL-1β and IL-33 comprise the IL-1 subfamily and bind the...

Oct 5, 2024 · The IL-1 Receptor (IL-1R) family includes signalling receptor complexes, decoy receptors, and negative regulators. Activation of IL-1β target cells occurs through interaction with the type I receptor (IL-1RI) and an additional IL-1 receptor protein.

Jan 18, 2010 · Although all the cytokines are extracellular, only IL1RN (the gene that encodes IL-1Ra) encodes a classical signal peptide that enables secretion of the cytokine by the endoplasmic reticulum and...