Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory cytokine interleukin 17A, a member of IL-17 family ligands …

Oct 11, 2023 · Interleukin 17 (IL-17) is an important cytokine that has several roles in host defense responses against mucosal infections; additionally, it is a primary pathologic cytokine …

IL-17F utilizes IL-17RA and IL-17RC as its receptors and activates the MAP kinase-related pathway. IL-17F is derived from several cell types such as Th17 cells, mast cells and …

Nov 19, 2019 · IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease …

Detailed sequence analysis of IL-17R family members revealed the presence of a conserved intracellular subdomain with homology to Toll-IL-1R (TIR) domains, which are essential for …

Jul 3, 2009 · This report describes the cloning of the first IL-17R family member, and is the first to show a role for NF-κB in IL-17-induced signal transduction.

IL-17 cytokine family members induce downstream signaling through interactions with a specific cell surface receptor complex, but the nature of this receptor is poorly understood. The IL-17 …

The IL-17 family consists of six members IL-17A-F, while the IL-17 receptor family consists of five members IL-17RA to IL-17RE. IL-17RA is a common receptor that forms heterodimeric …

Sep 2, 2024 · Interleukin‑17 (IL‑17), an inflammatory cytokine primarily secreted by T helper 17 cells, serves a crucial role in numerous inflammatory diseases and malignancies via its …

Sep 12, 2023 · Here, we show that a molecular complex containing the adaptor molecule Act1 and tyrosine phosphatase SHP2 mediated autonomous IL-17R signaling that accelerated and …