IL-17A receptor A (IL-17RA) was first isolated and cloned from mouse EL4 thymoma cells and the bioactivity of IL-17A was confirmed by stimulating the transcriptional factor NF-kappa B activity and interleukin-6 (IL-6) secretion in fibroblasts. [13]

Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of ...

IL-17RA binds both IL-17A and IL-17F and is expressed in multiple tissues: vascular endothelial cells, peripheral T cells, B cell lineages, fibroblast, lung, myelomonocytic cells, and marrow stromal cells.

Oct 11, 2023 · IL-17A and IL-17F activate downstream signaling pathways for signal transduction, primarily through IL-17RA and IL-17RC heterodimers.

Given the role of IL-4 and IL-17A played in disease severity and airway remodeling [4,30], we thus hypothesized that IL-4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu that favors TGF-β 1 to induce EMT during the process of airway remodeling in severe asthma. To test this hypothesis, we performed studies in 16HBE cells, an ...

Apr 16, 2019 · Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-17 signal transduction regulation.

Jul 29, 2020 · This article focuses on the mechanisms by which FLG, LOR, and IVL expression is regulated by IL-4, IL-13, IL-22, and IL-17A. The author also summarizes how AHR and NRF2 dual activators exert their beneficial effects in the treatment of AD.

Jul 15, 2013 · In summary, we provided the first evidence supporting that Th2 and Th17 derived cytokines, IL-4 and IL-17A, synergize with TGF-β 1 to promote airway remodeling during the course of severe asthma, in which IL-4 and IL-17A provide a chronic inflammatory milieu that favors TGF-β 1 to induce bronchial EMT. This synergic action is coordinated by ...

IL-17E (IL-25) is a little unusual amongst the IL-17 family: while other IL-17 family members promote neutrophilic responses, IL-25 uniquely induces expression of IL-4, IL-5, IL-13, and TSLP, all associated with type 2 immunity.

Aug 21, 2019 · We have now unveiled a novel role for IL-17A in repairing and/or enhancing TJ epidermal barrier function. In this work, we demonstrated that IL-17A enhances TJ integrity at an early time point in differentiating PHK (Figure 1) and this was associated with enhanced expression of CLDN4 (Figure 4).