IL-17RA binds both IL-17A and IL-17F and is expressed in multiple tissues: vascular endothelial cells, peripheral T cells, B cell lineages, fibroblast, lung, myelomonocytic cells, and marrow …

IL-17A/F heterodimerization is enabled by a small conserved hydrophobic core and the structural versatility of divergent N-terminal sequences. The dimer interface of IL-17A/F is very large …

Interleukin (IL)-17 plays a critical role in inflammation. Most studies to date have elucidated the inflammatory role of IL-17A, often referred to as IL-17. IL-17F is a member of the IL-17 family …

Oct 11, 2023 · Interleukin 17 (IL-17) is an important cytokine that has several roles in host defense responses against mucosal infections; additionally, it is a primary pathologic cytokine …

Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity …

Apr 16, 2019 · Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, …

IL-17A, F, and A/F in Infection. IL-17A and IL-17F evolved to protect from infection, and it is now clear that they orchestrate protective responses against infections at mucosal and epithelial …

Jul 24, 2023 · The pleiotropic ability of cytokines such as IL-17A and IL-17F to regulate inflammatory processes and tissue repair is being unveiled at a fast pace and is of immense …

Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with a viral gene (O40633). [5][6] The protein …

In this issue of Immunity, Ishigame et al. (2009) show that interleukin-17A (IL-17A) mediates autoimmunity whereas both IL-17A and IL-17F are required for mucosal immunity. IL-17A may …