Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, [1] macrophages, neutrophils, helper T cells and human B- lymphoblastoid cells (NC-37) in …

The IL-12 receptor (IL-12R), composed of interleukin 12 receptor beta 1 (IL-12Rβ1) and Interleukin 12 receptor beta 2 (IL-12Rβ2) chains, mediates signal transduction, which involves …

Feb 1, 2003 · Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ),...

Binding of IL-12 to the IL-12 receptor (IL-12R) on T and natural killer (NK) cells leads to signaling via signal transducer and activator of transcription 4 (STAT4) and subsequent interferon …

Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12 and consisting of beta 1 [1] and beta 2 subunits. [2] ^ Chua AO, Chizzonite R, Desai BB, Truitt TP, Nunes P, Minetti LJ, …

Feb 21, 2025 · In this work, we have generated bispecific interleukin (IL)-12 surrogate agonists based on camelid-derived single-domain antibodies (sdAbs) targeting the IL-12 receptor (IL …

Feb 18, 2021 · Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines that are produced by antigen-presenting cells to regulate the activation and differentiation of lymphocytes, and they …

In human primary B cells, Durali et al. found a functional IL-12 receptor (IL-12R) that internalizes following IL-12 binding. IFN-γ and, to a lesser extent, IL-12 positively regulated the IL-12Rβ2 …

Mar 1, 2025 · Interleukin-12 (IL-12) regulates the differentiation of CD4 + T lymphocytes into Th1 cells by binding to its receptor, thereby promoting cellular immunity.

The IL-12 family of cytokines is comprised of IL-12, IL-23, IL-27, IL-35, and IL-39. This family of cytokines is biologically distinct in that they are composed of functional heterodimers, which …