The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury. It is not surprising ...

This pathway summarizes extracellular and intracellular signaling of IL-1α or IL-1β, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response.

Jan 19, 2010 · This pathway summarizes extracellular and intracellular signaling of IL-1alpha or IL-1beta, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response.

IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream processes to affect both innate and adaptive immunity. Multiple studies show that IL-1β is typically activated in macrophages after inflammasome sensing of infection or danger, leading to caspase-1 processing of IL-1β and its release.

Jan 19, 2010 · These signals activate the NALP3-inflammasome pathway, which plays a central role in acute and chronic sterile inflammation. Here, we describe the essential components of the NALP3-inflammasome that control processing and release of IL-1β.

Feb 23, 2010 · IL-1α and IL-1β are encoded by two separate genes. Both proteins are synthesized as pro-peptide precursors (pro-IL-1α and pro-IL-1β) without a signal sequence, so are secreted via an...

IL-1 family cytokines activate intracellular signaling pathways by binding to a primary receptor subunit, such as IL-1 RI/IL-1 R1, IL-18 R alpha/IL-1 R5, IL-1 Rrp2/IL-1 R6, or ST2/IL-1 R4, which then recruits an accessory receptor to form the active receptor complex.

Secretion of IL-1 beta is blocked by methylamine, low temperature or serum free medium, and is increased by raising the culture temperature to 42 degrees C or by the presence of calcium ionophores, brefeldin A, monensin, dinitrophenol or carbonyl cyanide chlorophenylhydrazone.

Mar 1, 2025 · Once released, IL-1β binds to IL-1 receptor 1 (IL-1R1) in conjunction with IL-1 receptor accessory protein (IL-1R3), forming a signaling complex. This signaling complex recruits the adapter protein MyD88 which further activates IRAK kinases and TRAF6, leading to NF-κB and MAPK activation.

This review highlights the different models of a non-classical secretory pathway used by monocytes, macrophages and dendritic cells to export the leaderless cytokine IL-1beta.