The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.

The IL-1 family of cytokines and receptors broadly affects a broad spectrum of immunological and inflammatory responses. 6 As shown in Figure 1, the 11 members of the IL-1 family are …

Jan 18, 2010 · This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, …

Jun 6, 2019 · From a historical point of view, IL-1 has a wide range of biological functions, which include acting as a leukocytic pyrogen, a mediator of fever and a leukocytic endogenous …

IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has …

The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of …

Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. [5][6] In general, Interleukin 1 is …

Interleukin 1 (IL-1) is a pro-inflammatory cytokine that plays a key role in the development and regulation of nonspecific defense and specific immunity. However, its regulatory influence …

The classical interleukin-1 (IL-1) family cytokines, IL-1α and IL-1β, as well as IL-18, play key roles in inflammation. Recently, other members of the IL-1 family have been identified.

Jan 19, 2010 · This pathway summarizes extracellular and intracellular signaling of IL-1alpha or IL-1beta, including positive- and negative-feedback mechanisms that amplify or terminate the …