Mar 17, 2025 · Understanding IL-2’s receptor composition, signaling dynamics, and functional outcomes provides insights into both normal immune responses and pathological conditions …

Aug 8, 2018 · IL-2 interacts with three classes of IL-2 receptor with different affinities for IL-2; IL-2 binds with low affinity (K d ~10 −8 M) to receptors containing only IL-2Rα, with intermediate ...

This pathway summarizes extracellular and intracellular signaling of IL-1α or IL-1β, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response.

This review focuses on our current understanding of the biological role of IL-2 with an emphasis on the intracellular signaling pathways controlled by IL-2 in T cells, and factors that might …

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the …

IL-18-mediated signaling acts as one of the vital components of the immunomodulatory cytokine networks involved in host defense, inflammation, and tissue regeneration. Albeit its biomedical …

View our interactive IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types.

Overview of IL-2 Signaling Pathways. Interleukin-2 (IL-2) is an O-glycosylated four alpha-helix bundle cytokine that is primarily produced by activated T cells, dendritic cells, and B cells.

Mar 17, 2025 · This review highlighted the characterization of IL-2R as a multi-chain receptor complex set a precedent for decoding cytokine receptor signaling. The unique interplay …

Jan 15, 2025 · IL-2 dynamics play a critical role in receptor binding and signaling, which could be leveraged for engineering novel IL-2-based therapies. Human interleukin-2 (IL-2) is a crucial …