Cross-regulation of Signaling and Immune Responses by IFN-γ and STAT1
The major STAT protein activated by IFN-γ is STAT1. Many IFN-γ functions are mediated by direct activation of immune effector genes by STAT1, including genes encoding anti-viral …
Targeting IFN/STAT1 Pathway as a Promising Strategy to …
In this review, we summarized the current knowledge of radioresistance mediated by the IFN/STAT1 pathway, with a particular focus on the oncogenic function of STAT1 signaling and …
IFNγ: signalling, epigenetics and roles in immunity ... - Nature
Jun 19, 2018 · Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical …
Constitutive and IFN-γ-induced nuclear import of STAT1 proceed …
STAT1 functions as both a constitutive transcriptional regulator and, in response to cytokine stimulation of cells, as an inducible tyrosine-phosphorylated transcription factor. Here, we …
IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue ...
Sep 30, 2023 · Using transcriptome-wide approaches, our study demonstrates that aging intestinal stem cells strongly upregulate antigen presenting pathway genes and over-express …
Stat1-dependent and -independent pathways in IFN-γ …
Feb 1, 2002 · The immediate-early genes c-Jun, JunD and EGR-1, and the chemokines MIP-1α and MCP-1 are regulated by IFN-γ in a Stat1-independent manner. Temporal expression …
Modulation of the activation of Stat1 by the interferon-gamma ... - PubMed
Modifying Stat1 activation by IFN-gamma may have pharmacological benefits. We report that the rate of activation of Stat1 can be altered in HeLa cells by overexpressing either the IFN …
Stat1-dependent and -independent pathways in IFN-gamma
The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the …
Unique aspects of IFN-γ/STAT1 signaling in neurons - PubMed
In this review, we discuss the neuron-specific mechanisms and kinetics of IFN-γ/STAT1 activation, the potential sources and entry sites of IFN-γ in the CNS, and the diverse set of …
Modulation of the activation of Stat1 by the interferon-γ receptor ...
Jan 16, 2006 · Modifying Stat1 activation by IFN-γ may have pharmacological benefits. We report that the rate of activation of Stat1 can be altered in HeLa cells by overexpressing either the …
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