IFNG, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoan infections. IFNG is an important activator of macrophages and inducer of major histocompatibility complex class II molecule expression.

Jun 19, 2018 · Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated...

Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now known to represent a distinct member of the IFN family and plays critical roles not only in orchestrating both innate and adaptive immune responses ...

Interferon‐gamma (IFN‐γ) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN‐γ are mediated by its heterodimeric cell‐surface receptor (IFN‐γR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression.

Interferon (INF)-gamma is a cytokine encoded for by the IFNG gene and has serves multiple regulatory roles within both the innate and adaptive immune systems.

Jun 11, 2020 · IFNγ acts on its receptor to induce rapid and transient Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signalling and interferon-stimulated gene (ISG) induction.

Jun 21, 2021 · Interferon-γ (IFNγ) is a cytokine that has both protumour and antitumour activities, suggesting that it may serve as a nexus for responsiveness to immunotherapy. Many cancer immunotherapies...

Jun 1, 2023 · Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and …

Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and regulates cellular apoptosis and proliferation.

Sep 29, 2020 · Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer.