Aug 22, 2003 · In the present study, we provide evidence that Stat5 is phosphorylated on serines 725/730 in an IFNα- and IFNβ-dependent manner, providing direct evidence that serine phosphorylation of the protein is a component of an interferon signaling cascade.

May 1, 2005 · IFN-γ, the only type II IFN, initiates signalling by binding a distinct receptor at the cell surface. Type I and type II IFNs activate both common and distinct STAT (signal transducer and...

Results of this study suggested that STAT5 is essential for IFN-β-mediated mitochondrial homeostasis and that the IFN-β/STAT5 molecular cascade could be a potential therapeutic target for neurodegenerative diseases.

Jan 15, 2005 · Engagement of the IFN-alphabeta receptor initiates multiple signaling cascades, including activation of the STAT. In this study, we demonstrate that IFN-alphabeta, although antiproliferative in wild-type CD4(+) or CD8(+) T cells, act as strong mitogens on their STAT1(-/ …

To analyze Treg STAT5 signaling in response to antigen-specific stimulation ex vivo, we have chosen commercially available tubes from the whole blood Interferon-γ Release immune Assay (IGRA), which uses mixtures of SARS-CoV-2 S proteins selected to …

Jun 15, 2014 · IL-2 greatly increases IFN-γ production in hDCs by phosphorylating STAT5, thus leading to increased ability of hDCs to activate helpless CD8 + T lymphocyte cytotoxicity. PBMCs were obtained from cytapheresis of healthy volunteers who …

Jun 1, 2021 · IFN-β induces events that are required for mitochondrial fission, phosphorylating STAT5 and upregulating PGAM5, which phosphorylates serine 622 of Drp1. IFN-β signaling then recruits Drp1 to mitochondria, oligomerizes it, and engages INF2 to stabilize mitochondria-endoplasmic reticulum (ER) platforms.

Nov 15, 2004 · In this study we demonstrate CD2-mediated activation of the newly characterized −3.6-kb IFN-γ STAT5 binding region. CD2 signaling of human PBMC results in activation of the −3.6-kb IFN-γ promoter, whereas mutation of the −3.6-kb STAT5 site attenuates promoter activity.

STAT5 is known to be activated by IFN-α in embryonic fibroblasts . Knockdown of STAT5 expression in HT22 cells prevented the inhibition of DEX-induced MMTV-luciferase activity by IFN-α . This indicates that STAT5 has a role in repressing GR mediated gene transcription.

Aug 22, 2003 · In the present study, we provide evidence that Stat5 is phosphorylated on serines 725/730 in an IFNalpha- and IFNbeta-dependent manner, providing direct evidence that serine phosphorylation of the protein is a component of an interferon signaling cascade.