STAT1 and STAT2 are the first STAT proteins identified in the IFN signal transduction pathways that have an essential role in suppressing tumor cell proliferation, differentiation, apoptosis and angiogenesis.

The major STAT protein activated by IFN-γ is STAT1. Many IFN-γ functions are mediated by direct activation of immune effector genes by STAT1, including genes encoding anti-viral proteins, microbicidal molecules, phagocytic receptors, chemokines, cytokines, and …

Jun 24, 2020 · The interferon (IFN)-mediated activation of the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) signaling is crucial for cell sensitivity to ionizing radiation.

IFN- γ signaling induces phosphorylation of two STAT1 residues: Tyr 701 (Y701), which facilitates dimerization, nuclear translocation, and DNA binding; and Ser 727 (S727), which enables maximal STAT1 transcription activity.

Dec 23, 2013 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage and preventing autoimmunity.

Oct 3, 2004 · Here we show that interferon-α (IFN-α)–induced activation of the transcriptional activator STAT1 and inflammatory STAT1 target genes was enhanced in IFN-γ-primed macrophages.

May 31, 2012 · STAT1 is a cytoplasmic protein that, upon awakening from dormancy by signaling from IFNs and other factors, activates numerous genes designed, in principle, to defend the host (1–3).

Jun 1, 2012 · Although the activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-suppressive functions, emerging data indicate that expression of the STAT1 pathway confers cellular resistance to DNA-damaging agents …

Mar 20, 2025 · IFN-γ promotes tumorigenicity and metastasis in a syngeneic mouse model of melanoma, and this effect is STAT1-dependent and associated with the influence of IFN-γ on γδ T-cells . IFN-γ contributes to melanoma progression, which can be suppressed by targeting neuronal nitric oxide synthase (nNOS) [ 20 ].

The IFN-γ/STAT1 immune signaling pathway impacts many homeostatic and pathological aspects of neurons, beyond its canonical role in controlling intracellular pathogens. Well known for its potent pro-inflammatory and anti-viral functions in the periphery, the IFN-γ/STAT1 pathway is rapidly activated …