Molecular mechanisms of IFN-gamma to up-regulate MHC class I …
IFN-gamma binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via phosphorylation of JAK and STAT1 in cells. IFN-gamma up-regulates MHC class I antigen …
Systemic Interferon-γ Increases MHC Class I Expression and T-cell ...
IFNγ changed the SS and MRCL TME, inducing tumor-surface MHC-I expression and significant T-cell infiltration (P < 0.05). Gene-expression analysis suggested increased tumor antigen …
IFN-α induces a preferential long-lasting expression of MHC ... - PubMed
These observations suggest that IFN-α-stimulated long-lasting MHC class I expression may amplify beta cell antigen presentation during the early phase of type 1 diabetes and that IFN-α …
Chemical and genetic control of IFNγ‐induced MHCII expression
We describe novel pathways and drugs related to oxidative conditions in cells impacting on IFNγ‐mediated MHCII expression, which provide a molecular basis for the understanding of …
Systemic Interferon-γ Increases MHC Class I Expression and T-cell ...
IFNγ can enhance expression of surface major histocompatibility complex (MHC) molecules and increase the processing and presentation of tumor-specific antigens [7], thus facilitating T-cell …
Interferon Gamma, MHC Class I Regulation and Immunotherapy
Nov 30, 2021 · The activation of endogenous IFN? signaling pathway or the administration of recombinant IFN? increases the expression of MHC-I. MHC-I molecules are core elements for …
Systemic Interferon-γ Increases MHC Class I Expression and T-cell ...
Aug 1, 2019 · IFNγ changed the SS and MRCL TME, inducing tumor-surface MHC-I expression and significant T-cell infiltration (P < 0.05). Gene-expression analysis suggested increased …
Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I …
Aug 13, 2009 · IFN-γ up-regulates MHC class I antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-γ to enhance MHC class I antigen …
IFN-γ调控MHC I，介导双重肿瘤免疫_细胞_基因_缺失 - 搜狐
Mar 4, 2023 · IFN作为肿瘤免疫监控的重要组成，肿瘤对IFN感知（sensing）的丢失能够使大多数肿瘤对免疫检查抑制剂 (ICB)敏感。 IFNγ对肿瘤细胞的免疫激活活性，很大程度上归因于诱导 …
IFN-γ–dependent tumor-antigen cross-presentation by ... - Science
Jun 8, 2022 · Recently, we demonstrated that IFN-γ signaling induces the up-regulation of major histocompatibility complex (MHC) class II molecules by tumor LECs, which locally promote the …