Jun 8, 2022 · Here, we assessed the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response. Interferon-γ (IFN-γ) …

Dec 6, 2022 · By generating Tbk1-KO MC38 cells, where IFN production is lost without manipulating dsDNA or 2′3′-cGAMP levels, we evaluated the specific role of cancer cell …

Jul 9, 2024 · For LC3 detection, MC38 cells cultured in six-well plates were treated with 1 μg/mL recombinant IFN-α or 100 ng/ml recombinant IFN-γ for 48 h with or without 50 μM chloroquine …

Sep 26, 2023 · We observe upregulation of poly-ADP ribosyl polymerase 14 (PARP14) in chronic IFNγ-treated cancer cell models, in patient melanoma with elevated IFNG expression, and in …

To investigate the effects of type I IFN signaling in cancer cells, we prevented this signaling in 4 murine cancer cell lines: MC38 (colorectal carcinoma), B16F10 (melanoma), KPC (pancreatic …

Jan 2, 2024 · Here, we showed that IFITM3-deficient Tregs blunted tumor growth by strengthening the tumor-killing response and displayed the Th1-like Treg phenotype with …

Oct 7, 2021 · We show that interferon-γ (IFN-γ) reduced tumor progression in mouse models of B-cell acute lymphoblastic leukemia (B-ALL) and colorectal carcinoma (MC38). Its activity …

Dec 15, 2023 · IFN-γ increased STAT1 protein levels in MC38 wt (Fig. 3A and B) and CT26 wt cells (Fig. S4B and C) to the same degree under A IFN−γ and N IFN−γ conditions without …

Apr 20, 2023 · MC38 colon adenocarcinoma is a widely used preclinical model, yet how it recapitulates human colorectal cancer remains poorly defined. This study investigated the …

Aug 8, 2019 · The binding of the IFN fusion proteins to murine PD-L1 was evaluated by FACS analysis against the murine PD-L1-expressing MC38 cell line. The anti-PD-L1-IFN-α retains …