An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. [1] [2] Interferons bind to receptors on the surface of a cell, initiating protein …

Sep 29, 2019 · IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs). Remarkably, approximately …

In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production. Next, we describe ways in which ISGs both …

Dec 23, 2013 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage …

Many viruses trigger the type I interferon (IFN) system, leading to the transcription of hundreds of interferon-stimulated genes (ISGs). The products of these ISGs exert numerous antiviral …

In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal viral infection. IFNs are secreted cytokines that activate a signal transduction cascade leading to …

Mar 4, 2019 · Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread.

Jul 7, 2018 · Interferon-stimulated genes (ISGs) are the effectors of interferon (IFN) actions and play major roles in innate immune defense against microbial infection.

Sep 20, 2024 · Non-canonical ISG induction provides a rapid, IFN-independent antiviral response, crucial for early defense against viral infections. This pathway operates quickly, often within …

Oct 1, 2024 · We can distinguish between robust and tunable ISG for IFN-I. Robust ISG respond to all IFN subtypes and to low IFN doses, whereas tunable genes show variable responses to …