Interferon Type I (α/β/δ...) The molecular structure of human interferon-beta (PDB: 1AU1 ). The type-I interferons (IFN) are cytokines which play essential roles in inflammation, …

May 1, 2005 · There are two main classes of interferon (IFN): type I IFNs and type II IFN. There are many type I IFNs, including IFN-α, IFN-β and IFN-ω, and all of these bind a common cell …

Jan 23, 2015 · Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the...

Dec 23, 2013 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage …

Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune …

The type I IFN genes exhibit diverse biological functions in cellular immunity. IFN-α plays a role in several autoimmune diseases, including lupus and myositis. Clinical trials with anti-IFN-α …

Interferons (IFN s, / ˌɪntərˈfɪərɒn / IN-tər-FEER-on[1]) are a group of signaling proteins [2] made and released by host cells in response to the presence of several viruses. In a typical …

Type I IFN excess is associated with disease severity, autoantibodies, and could potentially predict response to newer therapies targeting type I IFN pathways. Herein, we provide an …

Dec 18, 2016 · Within the immunological milieu, Type I interferons (IFN-I) play a central role in driving an antiviral state in non-immune cells as well as orchestrating antiviral immune …

May 7, 2024 · Type I interferons (IFN-I) represent a group of pleiotropic cytokines renowned for their antiviral activity and immune regulatory functions. A multitude of studies have unveiled a …