Interferon Type I (α/β/δ...) The molecular structure of human interferon-beta (PDB: 1AU1 ). The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses.

Mar 30, 2025 · IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Multisystem Inflammatory Syndrome In Children and Secondary Progressive Multiple Sclerosis. Among its related pathways are Overview of interferons-mediated signaling pathway and SARS-CoV-2 Infection.

Interferon beta is a protein that in humans is encoded by the IFNB1 gene. [5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

Feb 8, 2025 · Gene target information for IFNB1 - interferon beta 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Type I IFNs impact B-cell function through a variety of mechanisms, including effects on receptor engagement, Toll-like receptor expression, cell migration, antigen presentation, cytokine responsiveness, cytokine production, survival, differentiation and class-switch recombination.

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs).

It is now known that type I IFNs (IFNα and IFNβ) are the major contributors in innate immunity serving as the first line of defense against viruses. They are more than just anti-virals as they play a major role in linking innate to adaptive immunity.

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections.

Type I interferons (IFNs) are potent regulators of both innate and adaptive immunity. All type I IFNs bind to the same heterodimeric cell surface receptor composed of IFN-alpha receptor (IFNAR-1) and IFN-alpha/beta receptor (IFNAR-2) polypeptides.

Dec 10, 2024 · Consistent with the enhanced TI-2 immune responses in SCD mice, the frequencies of B-1b cells (B-1 cells in humans), a major cell type responding to TI-2 antigens, were significantly increased in both the peritoneal cavity and spleens of SCD mice and in blood of patients with SCD.