Interferon Type I (α/β/δ...) The molecular structure of human interferon-beta (PDB: 1AU1 ). The type-I interferons (IFN) are cytokines which play essential roles in inflammation, …

Jan 23, 2015 · Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the...

Type I IFNs elicit antiviral, antiproliferative and immunomodulatory responses by binding to the type I interferon receptor. The receptor consists of the IFNAR1 and IFNAR2 transmembrane …

May 1, 2005 · There are two main classes of interferon (IFN): type I IFNs and type II IFN. There are many type I IFNs, including IFN-α, IFN-β and IFN-ω, and all of these bind a common cell …

Dec 23, 2013 · Type I interferon (IFN) responses are regulated by host, pathogen and environmental factors. These factors calibrate the host defences while limiting tissue damage …

Type I interferons (IFNs) are polypeptides that are secreted by infected cells and have three major functions. First, they induce cell-intrinsic antimicrobial states in infected and neighbouring cells …

Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune …

Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections, as well as activating key components of the innate and …

Dec 20, 2023 · Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus …

Mar 1, 2024 · Interferons (IFNs) type I, particularly IFN-α, are central mediators in the pathogenesis of several Immune-mediated inflammatory diseases (IMIDs). IFN-blocking …