Mar 30, 2025 · IFIH1 (Interferon Induced With Helicase C Domain 1) is a Protein Coding gene. Diseases associated with IFIH1 include Singleton-Merten Syndrome 1 and Aicardi-Goutieres Syndrome 7. Among its related pathways are DDX58/IFIH1-mediated induction of interferon-alpha/beta and SARS-CoV-2 Infection.

Mar 30, 2014 · We found that heterozygous mutations in the cytosolic double-stranded RNA receptor gene IFIH1 (also called MDA5) cause a spectrum of neuroimmunological features consistently associated with an...

The IFIH1 gene provides instructions for making the MDA5 protein, which plays an important role in innate immunity, the body's early, nonspecific response to foreign invaders (pathogens) such as viruses and bacteria. Learn about this gene and related health conditions.

The IFIH1 gene encodes a cytoplasmic receptor that senses dsRNA viral products to activate type I interferon signaling through the MAVS (609676) adaptor molecule. This can inhibit virus replication and modulate cellular immune responses.

Feb 9, 2025 · Gene ID: 64135, updated on 9-Feb-2025. IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response.

The IFIH1 gene encodes for the MDA5 pattern recognition receptor, i.e., the interferon-induced helicase C domain-containing protein 1, also known as the melanoma differentiation associated protein 5 (MDA5), that acts as a key sensor of pathogen-associated molecular patterns (PAMPs)-containing viral nucleic acids.

Dec 10, 2024 · Gene target information for IFIH1 - interferon induced with helicase C domain 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Jan 4, 2025 · IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons.

Nov 9, 2024 · Interferon-induced helicase C domain-containing protein 1 (IFIH1, also known as MDA5; melanoma differentiation associated gene 5 protein) is one of the main PRRs that first sense viral RNA and activate host cells to produce interferon (IFN) in order to mount an effective antiviral immunity [7].

Ascertaining patients through a European and North American collaboration, we set out to describe the molecular, clinical and interferon status of a cohort of individuals with pathogenic heterozygous mutations in IFIH1.