Immediate-Early (IE) gene regulation of cytomegalovirus: IE1
In this review, we will summarize the documented biological functions of IE1 and pp71 proteins, especially with regard to how they counteract cellular intrinsic defenses. Keywords: …
Cytomegalovirus immediate-early 1 proteins form a structurally
Aug 9, 2021 · Our data demonstrate that the IE1 CORE domains of primate and rodent cytomegaloviruses form a unique protein class and display high structural similarity, strongly …
Human Cytomegalovirus Major Immediate Early 1 Protein Targets …
The 72-kDa immediate early 1 (IE1) protein encoded by human cytomegalovirus (hCMV) is a nuclearly localized promiscuous regulator of viral and cellular transcription. IE1 has long been …
The Human Cytomegalovirus Major Immediate-Early Proteins as …
IE1 is proposed to antagonize the type I IFN-mediated antiviral host cell response by at least two distinct mechanisms. The first mechanism depends on binding of IFN-activatable STAT2 to the …
6TGZ: IE1 from human cytomegalovirus - RCSB PDB
Nov 18, 2019 · IE1 interacts directly with PML, the key protein of PML-NBs, through its core domain and disrupts the dot-like multiprotein complexes thereby abrogating the antiviral …
Human cytomegalovirus IE1 protein alters the higher-order …
Jan 26, 2016 · Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger …
Ability of the Human Cytomegalovirus IE1 Protein To Modulate ...
Oct 15, 2003 · In one of the earliest events in human cytomegalovirus (HCMV)-infected cells, the major immediate-early (IE) protein IE1 initially targets to and then disrupts the nuclear …
The highly conserved basic domain I of baculovirus IE1 is
The immediate-early protein IE1 is the principal transcriptional regulator of the baculovirus Autographa californica nucleopolyhedrovirus (AcMNPV). Transactivation by IE1 is dramatically …
The Acidic Activation Domain of the Baculovirus Transactivator IE1 ...
IE1 contains an acidic activation domain (AAD) at the N terminus that is essential for transcriptional transactivation, but its role in viral DNA replication is unknown. In this study the …
The Highly Conserved Basic Domain I of Baculovirus IE1 Is …
Analysis of a panel of IE1 insertion mutations indicated that disruption of a highly conserved domain (residues 152 to 161) consisting of mostly positive-charged residues (basic domain I) …