Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD …

Mar 30, 2025 · IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) is a Protein Coding gene. Diseases associated with IDH2 include D-2-Hydroxyglutaric Aciduria 2 and Multiple Enchondromatosis, …

The IDH2 gene provides instructions for making an enzyme called isocitrate dehydrogenase 2. Learn about this gene and related health conditions.

Aug 31, 2022 · What Is an Isocitrate Dehydrogenase-2 (IDH2) Mutation? The isocitrate dehydrogenase-2 (IDH2) mutation is associated with some types of cancer such as acute …

IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-kappaB signaling to promote colorectal cancer progression. IDH2 stabilizes HIF-1alpha …

Aug 4, 2024 · Title: IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression.

Apr 26, 2021 · This review will focus on the biological roles of IDH2 mutation in tumorigenesis, and provide a proof-of-principle for the development and application of IDH2 mutant inhibitors …

Mar 17, 2025 · Mutations in the isocitrate dehydrogenase 2 (IDH2) gene play a key role in AML pathogenesis, disrupting cellular metabolism and epigenetic regulation. IDH2 encodes an …

Jul 17, 2024 · Although the literature is heterogeneous, generally IDH mutated (IDH1 and IDH2) tumors are more likely to also have MGMT methylation (80% for IDH-mutant compared to 60% …

IDH2 is a mitochondrial NADP-dependent isocitrate dehydrogenase (EC 1.1.1.42) that catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH. By providing …