Emerging Roles of Wild-type and Mutant IDH1 in Growth, …
Apr 30, 2021 · In this chapter, we introduce the current understanding of the biological roles of wild-type and mutant IDH enzymes in glioblastoma. We discuss the challenges hampering the …
IDH1 and IDH2 Mutations in Gliomas - PMC
Gliomas with mutated IDH1 and IDH2 have improved prognosis compared to gliomas with wild-type IDH. Mutated IDH can now be detected by immunohistochemistry and magnetic …
Updates in IDH-Wildtype Glioblastoma - PMC
The distinction between IDH -mutant vs wildtype gliomas has also become clearer, with the omission of “secondary” or IDH -mutant GBM in favor of the term diffuse IDH -mutant …
Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM
We present a GBM-specific deep-learning model for IDH mutation prediction, with a maximal accuracy of 83% on rCBV maps. Highest predictivity achieved on perfusion images possibly …
The implications of IDH mutations for cancer development and …
Jun 15, 2021 · Mutations in IDH1 or IDH2 are frequent among several cancer types with various tissues of origin; the resultant mutated enzymes have neomorphic activity that leads to …
Wild-type isocitrate dehydrogenase under the spotlight in …
Nov 11, 2021 · Over the past decade, extensive research has been done on mutant IDH enzymes as markers of good prognosis in glioblastoma, a highly aggressive brain tumor in adults with …
IDH Wild-Type Glioblastoma: Distinctions, Pathways, Prognosis
Mar 13, 2025 · IDH-mutant glioblastomas often arise from lower-grade gliomas and progress more slowly, whereas IDH wild-type glioblastomas develop de novo, exhibiting aggressive …
Deep Learning Can Differentiate IDH-Mutant from IDH-Wild …
Apr 9, 2021 · We present a GBM-specific deep-learning model for IDH mutation prediction, with a maximal accuracy of 83% on rCBV maps. Highest predictivity achieved on perfusion images …
Potential Biomarkers for IDH-Mutant and IDH-Wild-Type ... - MDPI
5 days ago · The WHO’s latest classification system’s distinction between IDH-mutant and wild-type gliomas has highlighted significant survival differences between these molecular …
Wild-type and mutated IDH1/2 enzymes and therapy responses
Jan 25, 2018 · Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism, epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal …