IDH mutation in glioma: molecular mechanisms and potential
Apr 15, 2020 · Here we provide an overview of the latest findings in IDH-mutated human malignancies, with a focus on glioma, discussing unique biological signatures and proceedings …
Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for …
Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary brain tumors diagnosed in patients younger than 50, constituting an important cause of …
The implications of IDH mutations for cancer development and …
Jun 15, 2021 · The broad effects of IDH mutations on epigenetic, differentiation and metabolic programmes, together with their high prevalence across a variety of cancer types, early …
IDH Mutation in Glioma: Pathway Shifts and Prognosis
Feb 8, 2025 · Explore how IDH mutations influence glioma development, impact prognosis, and guide diagnostic and therapeutic strategies. Isocitrate dehydrogenase (IDH) mutations are a …
Heating Up IDH-Mutant Gliomas - The New England Journal of …
Dec 4, 2024 · A recent study unpicks a key immune-mediated mechanism of mutant IDH–blocking drugs such as vorasidenib in the treatment of IDH-mutant glioma.
Treatment and prognosis of IDH-mutant astrocytomas in adults
Aug 28, 2024 · Across all grades, the presence of an IDH mutation identifies a group of tumors with a more prolonged natural history and favorable prognosis than that of IDH-wildtype …
IDH Mutant Glioblastoma: Novel Therapeutic Advancements
Mar 13, 2025 · Glioblastoma is one of the most aggressive primary brain tumors, with limited treatment options and poor prognosis. However, a subset of glioblastomas harbor mutations in …
Prognostic implications of DNA methylation machinery (DNMTs
2 days ago · IDH-mutant gliomas typically display a hypermethylation phenotype (G-CIMP), whereas IDH-wildtype gliomas often exhibit global hypomethylation. Given the crucial role of …
Diffuse astrocytoma, AYA-type, frequently MAPK-altered: report of …
3 days ago · A putative molecular subtype of IDH-wildtype diffuse glioma with recurrent MAPK pathway alterations has recently been reported. By dimensionality reduction analysis of …
Potential Biomarkers for IDH-Mutant and IDH-Wild-Type ... - MDPI
5 days ago · The patients were categorized into two groups: IDH-mutant (n = 30) and IDH-wild-type (n = 36). We made a comparative assessment of demographic characteristics, clinical …