Intracerebroventricular injection (often abbreviated as ICV injection) is a route of administration for drugs via injection into the cerebral ventricles so that it reaches the cerebrospinal fluid (CSF).

目前AAV在神经系统研究中的注射方法主要有以下几种：脑实质内注射、静脉注射、脑室注射（ICV）、枕大池内注射（ICM）和鞘内注射（IT），其中ICV、ICM和IT注射是通过脑脊髓液进行传递。 每种注射方式各有优缺点，研究者可根据具体的研究对象以及实验方案，选择适合的注射方式，推荐进行预实验对实验效果做初步测试，以得到更优的选择方案。 脑立体定位注射，相比其他注射方式靶向性强，注射病毒体积小，但是侵入性也强，且对操作者具有很高的要求。 在立 …

To examine how a delivery route can impact efficacy, a direct comparison of intravenous (IV) and intracerebroventricular (ICV) delivery of AAV9- IGHMBP2 was performed. Using a low-dose, both IV and ICV delivery routes led to a significant extension in survival and increased body weight.

Oct 27, 2021 · ICM injection of AAV9 achieves widespread transgene delivery in both brain and spinal cord. This is a distinct benefit over intracerebroventricular (ICV) administration, which targets the brain.

In this review, we analyzed delivery methods for AAV-mediated gene therapy in past and current clinical trials. The delivery routes analyzed were direct intraparenchymal (IP), intracerebroventricular (ICV), intra-cisterna magna (CM), lumbar …

The most heavily researched strategies for CNS-directed AAV delivery are intracerebroventricular (ICV), intra-cisterna magna (ICM), intrathecal (IT), and intraparenchymal injections. ICV, ICM, and IT injections deliver vector into the CSF circulation via lateral ventricle, cisterna magna, or lumbar spinal cord space, respectively.

In this context, three main routes of injection have been used for AAVs: intrathecal (IT), intra-cisterna magna (ICM), and intracerebroventricular (ICV) (Figure 1 a).

Jul 1, 2018 · Intrathecal delivery methods include intracerebroventricular (ICV), intrathecal-lumbar and intracisternal routes. The ICV route enables the administration of drugs into a lateral cerebral ventricle via an implanted device (reservoir and catheter).

May 11, 2021 · Results demonstrated that choice of delivery method has important implications for AAV9 biodistribution. Notably, intracerebroventricular (ICV) and intracisternal magna (ICM) achieved broad and comparable distribution across most brain regions, as measured by copies of vector DNA in brain tissue.

Intrathecal delivery can be achieved by a lumbar puncture (LP) or intracisterna magna (ICM) injection, although ICM is not commonly used in clinical practice due to increased procedural risk.