The LD50 is defined as the lethal dose at which 50% of the population if killed in a given period of time; an LC50 is the lethal concentration required to kill 50% of the population.

Jun 17, 2016 · LD50 and LC50. LD50 (Lethal Dose 50%) is a statistically derived dose at which 50% of the animals will be expected to die. For inhalation toxicity, air concentrations are used for exposure values. Thus, the LC50 (Lethal Concentration 50%) is used.

Half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. [1] .

EC50--当试验不以死亡作为试验生物对毒物的反应指标，而是观察测定毒物对生物的某一影响，如鱼类失去平衡、畸形、酶活变化及藻类生长受抑制，常用有效浓度即EC（effective concentration）来表示毒物对试验生物的毒性。 EC50即指半数有效浓度，是指引起50％试验动物产生某一特定反应，或是某反应指标被抑制一半时的浓度。 LD是致死剂量，单位为mg/kg体重。 LD50——经口、经皮半数致死剂量。 较为简单的定义是指引起一群受试对象50%个体死亡所 …

IC50 (Inhibitory Concentration 50%) is the concentration of drug that is required for 50% inhibition of a cellular process in vitro. LC50 (Lethal Concentration 50%) is is the average...

In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.

Oct 5, 2012 · LD50 is the concentration causing 50% cell death (LD = lethal dose), although some people may have the opinion that LD50 should be reserved for in vivo studies only.

Jun 30, 2015 · "Therapeutic index is most commonly defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50), as determined in preclinical animal studies, [which] reflects the selectivity of a drug to elicit a desired effect rather than toxicity"

Dose response: EC50, ED50, LD50 Important definitions . The dose required to achieve . These are derived from bell curves; i.e. in a population of individuals, there will always be variation in drug response – but a majority of them will respond roughly the same way to this drug, and that’s the fat part of the bell curve. Dose

May 10, 2024 · LD 50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD 50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.