Mar 30, 2025 · YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with YY1 include Gabriele-De Vries Syndrome and Insulinoma. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang."

YY1 plays an important role in human disease, YY1 haploinsufficiency has been implicated in an intellectual disability syndrome, and YY1 overexpression occurs in many cancers.

Human transcription factor YY1 could upregulate the HIV-1 gene expression. YY1-induced upregulation of FOXP4-AS1 and FOXP4 promote the proliferation of esophageal squamous cell carcinoma cells. The CCDC43-ADRM1 axis regulated by YY1, promotes proliferation and metastasis of gastric cancer.

Human YY1 is a protein composed of 414 amino acids with a calculated molecular weight of 44kDa . YY1 contains four C2H2-type zinc fingers at the C-terminus (aa 295–414), which are responsible for sequence-specific binding to the consensus DNA recognition sequence: 5’-(C/g/a)(G/t)(C/t/a)CATN(T/a)(T/g/c)-3’ ( Hyde-DeRuyscher et al . 1995 ...

Nov 28, 2005 · YY1 is a ubiquitous and multifunctional zinc-finger transcription factor (also known as δ, NF-E1, UCRBP, and CF1) member of the Polycomb Group protein family, a group of homeobox gene...

Feb 8, 2025 · YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters.

Sep 30, 2020 · Human YY1 is composed of 414 amino acids. It binds a small DNA sequence (5′-CCGCCATNTT-3′) through the four C2H2-type zinc fingers located at the C-terminal of the protein (amino acid 296–320, 325–347, 353–377, 383–407).

Nov 16, 2020 · YY1 is highly conserved in vertebrates, where its homologs in human, chimpanzee, dog, mouse, rat and chicken share >80% amino acid sequence identity (Supplementary Fig. 4). YY1 contains a...

May 15, 2015 · Here, we present a study of the structural properties of human YY1 using several biochemical and biophysical techniques (fluorescence, circular dichroism, gel filtration chromatography, proteolytic susceptibility) together with various bioinformatics approaches.