5-hydroxytryptamine (serotonin) 1e receptor (5-HT 1e) is a highly expressed human G-protein coupled receptor [3] that belongs to the 5-HT1e receptor family (G i -coupled serotonin …

In this report, we provide the first evidence of 5-ht 1E receptor function in animal tissue, demonstrating that 5-ht 1E receptors couple to the inhibition of adenylate cyclase in guinea pig …

Analysis of the pharmacological properties of a series of chimeric 5-HT1D beta/5-HT1E receptors indicates that sequences in the sixth and seventh transmembrane domains are responsible for …

Mar 30, 2025 · HTR1E (5-Hydroxytryptamine Receptor 1E) is a Protein Coding gene. Diseases associated with HTR1E include Ocular Hypotension and Migraine With Or Without Aura 1. …

The 5-ht 1E receptor was first detected in human brain membranes (this is crucial, see below) using radioligand binding studies that found that [3 H]5-HT, in the presence of blocking agents …

Sep 18, 2023 · Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different receptors. These …

Quantitative RT-PCR of guinea pig brain regions has revealed high levels of gp5-HT 1E receptor mRNA in the cortex, hippocampus, and olfactory bulb and moderate expression in other …

Key results: High levels of 5-ht (1E) receptors are detected in olfactory bulb glomeruli as well as the molecular layer of the dentate gyrus (DG). In DG membranes, BRL54443, a 5-ht (1E) /5 …

The mRNA encoding the recently cloned 5-HT1E receptor, which has low affinity for the 5-HT1 receptor ligand 5-carboxamidotryptamine (5-CT), was localized in human brain. It was found to …

Jan 1, 1997 · Radioligand binding studies initially identified a putative receptor, termed 5-HT1E, in human cortex and putamen which was able to bind [3H]5-HT even in the presence of …