May 18, 2017 · Two serogroup B meningococcal (MenB) vaccines are currently licensed for use among persons aged 10–25 years in the United States: MenB-FHbp (Trumenba) and MenB-4C (Bexsero).

Feb 23, 2021 · An hSBA titer of at least 1:4 is widely accepted as a surrogate marker of protection against meningococcal disease 14. At present, the immunogenicity of MenB vaccines is measured against a...

We compared geometric mean titers (GMTs), calculated Pearson correlation coefficients between paired hSBA and rSBA results, and calculated sensitivity/specificity and likelihood ratios for an rSBA ≥8 or ≥128 for classifying hSBA ≥4, taking hSBA as the ‘gold standard’.

Original experiments on natural immunity established a titer of ≥4 as the correlate of protection for SBA assays using human complement (hSBA), but human complement is relatively difficult to obtain and standardize.

We predicted persistence of serum bactericidal activity against human complement (hSBA) titers 5 years after both a MenABCWY primary series and booster dose using a power law model (PLM).

hSBA titers of serum samples determined using independent pooled human complement (hC′) lots. Two-fold serum dilutions from 1:4 to 1:1,024 were tested. Titers of <4 are shown as values of 2.

Jul 22, 2021 · One month postbooster, 93.4-100.0% of subjects achieved hSBA titers ≥ lower limit of quantitation against each test strain; percentages at 12 and 26 months postbooster were higher than at similar time points following primary vaccination.

Jul 22, 2021 · Persistence of hSBA titers elicited by the meningococcal serogroup B vaccine menB-FHbp for up to 4 years after a 2- or 3-dose primary series and immunogenicity, safety, and tolerability of a booster dose through 26 months

Dec 14, 2017 · We used 14 meningococcal B test strains that expressed vaccine-heterologous factor H–binding proteins representative of meningococcal B epidemiologic diversity; an hSBA titer of at least 1:4 is...

Jul 21, 2016 · We conducted a seroprevalence survey among students to assess vaccination status and collect serum specimens to quantify titers of serum bactericidal antibodies (SBA) with an assay that included...