Nov 3, 2020 · Knockdown of the cell adhesion protein CDH1 in encapsulated hPSC aggregates resulted in protrusion morphologies and emergence of extra-embryonic lineages, whereas unencapsulated CDH1(-) aggregates displayed organized radial delamination and mesendoderm specification bias.

Feb 26, 2025 · Cadherin 1 (CDH1)-mediated cell–cell contacts maintain the hPSC colony core, while the peripheral cells bind to extracellular fibers, primarily vitronectin, collagens, or laminins via...

Nov 1, 2020 · CDH1 in encapsulated hPSC aggregates resulted in protrusion morphologies and emergence of extra-embryonic lineages, whereas unencapsulated CDH1(-) aggregates displayed organized radial delamination and mesendoderm specification bias.

May 12, 2020 · Here, we used plasma membrane profiling to directly measure cell-surface protein expression in naive and primed hPSC. This unbiased approach quantified over 1,700 plasma membrane proteins, including those involved in cell adhesion, signaling, and cell interactions.

Hepatocyte nuclear factor 1B (HNF1B) encodes a transcription factor expressed in developing human kidney epithelia. Heterozygous HNF1B mutations are the commonest monogenic cause of dysplastic kidney malformations (DKMs).

Nov 27, 2019 · Here, we combined genetic engineering with computational modeling, machine learning, and mathematical pattern optimization to create a data-driven approach to control hPSC self-organization by knock down of genes previously shown to affect stem cell colony organization, CDH1 and ROCK1.

Oct 1, 2024 · In this study, we introduced the human CDH1 and EGFP genes as a fusion protein into the AAVS1 locus using the CRISPR/Cas9 system in hFSiPS1 cells, a hiPSC line derived from human dermal fibroblasts (Uhm et al., 2017).

Jan 20, 2024 · CDH1, a PDX1 target in the rodent pancreas, has recently been confirmed to promote insulin (INS) secretion, resist apoptosis, glucotoxicity, lipotoxicity, and endoplasmic reticulum stress through a complex interaction with signaling pathways.

Nov 1, 2020 · Knockdown of the cell adhesion protein CDH1 in encapsulated hPSC aggregates resulted in protrusion morphologies and emergence of extra-embryonic lineages, whereas unencapsulated CDH1 (-)...

Oct 24, 2018 · We found that Cdh1 is highly expressed in human CD34 + HSPCs and downregulated in differentiated subsets; whereas, loss of Cdh1 restricts myeloid differentiation, supports B cell development and preserves immature short-term HSPCs without affecting proliferation or viability.