Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. [5] This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a …

Mar 30, 2025 · HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include Vertical Talus, Congenital and Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding.

Oct 27, 2021 · Univariate analysis revealed that low HOXD10 expression, complete surgical resection, postoperative radiotherapy, postoperative temozolomide chemotherapy and IDH1 mutation were all beneficial prognostic factors.

Jul 10, 2014 · HOX gene expression is altered in many cancers; previous microarray revealed changes in HOX gene expression in head and neck squamous cell carcinoma (HNSCC), particularly HOXD10. HOXD10...

HOXD10 is a tumor modulator that can either be a tumor-suppressor or a tumor-promoting gene. However, the role of HOXD10 in glioblastoma multiforme (GBM) remains unclear. Immunohistochemistry (IHC) was applied to detect protein expression of HOXD10 in GBM and normal brain tissue patients.

Homeobox D10, a tumor suppressor, inhibits the proliferation and migration of esophageal squamous cell carcinoma. The results indicated that completely different sets of transcription factors coregulate HOXA4 and HOXD10 (but not HOXA9) and their expression-correlated genes.

Apr 7, 2014 · The HOXD10 gene encodes a member of the HOXD cluster of homeobox genes that encode transcription factors involved in limb development (summary by Dobbs et al., 2006). Gene Function Tabin (1992) reviewed the role of HOX genes in limb morphogenesis.

HOXD10, a key regulator of cell-differentiated phenotype maintainence, has been demonstrated to be involved in the tumorigenesis of many human malignacies. However, the status of HOXD10 expression and its biological function in cholangiocellular carcinoma (CCC) remain to be clarified.

Title: Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Results show that HOXD10 promoter is hypermethylated in papillary thyroid cancer (PTC) tissues and its mRNA expression decreased.

Using transcription factor activity analysis, we identified the homeobox transcription factor HOXD10 to be specifically activated at early time points after VEGFR-3 stimulation, and to regulate expression of immediate early transcription factors, including NR4A1.