Mar 6, 2018 · Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain …

Here, we introduced a dual recombinase-mediated intersectional genetic lineage tracing approach, enabling precise investigation of AT2 cellular origins during lung homeostasis, …

We show that biophysical forces through normal respiratory motion actively maintain alveolar type 1 (AT1) cell identity and restrict these cells from reprogramming into AT2 cells in the adult lung.

Sep 23, 2019 · Unlike membrane-localized AT1 markers, HOPX was present in the nucleus and allowed reliable quantification, which showed expression in 28% of GFP cells in the mutant …

In addition to their distinct morphology, AT1 cells are distinguished by expression of a combination of markers, including aquaporin 5 (AQP5), podoplanin (PDPN), homeodomain-only protein …

We found that the adult AT1 cell population contains both Hopx + Igfbp2 + and Hopx + Igfbp2 − AT1 cells, which have distinct cell fates during alveolar regeneration.

Aug 28, 2018 · Homeobox only protein x (HOPX) contributes to the formation of distal lung during development. In adult lung, alveolar epithelial type (AT) I cells express HOPX and lineage …

利用该分子标记物，研究者发现出生后 AT1 细胞存在着两种细胞亚型： Igfbp2+Hopx+ 的 AT1 细胞和 Igfbp2-Hopx+ 的 AT1 细胞。 在新生小鼠的 AT1 细胞和再生新肺泡的 AT1 细胞中， …

We found that the adult AT1 cell population contains both Hopx+Igfbp2+ and Hopx+Igfbp2− AT1 cells, which have distinct cell fates during alveolar regeneration.

Activation of YAP in primary human bronchial epithelial cells induced AT1 cell signature genes HOPX, PDPN, and AQP5 (Lange et al., 2015). In the embryonic lung, activation of YAP by …