A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. Mutations in a homeobox may change large-scale anatomical features of the full-grown organism.

Homeobox genes are characterized by a conserved 180-bp DNA sequence coding for a 60-aminoacid DNA-binding domain called the ‘homeodomain’. They function as transcription factors recognizing specific DNA sequences and regulate target genes (McGinnis and Krumlauf, 1992; Quiring et al., 1994).

Oct 11, 2010 · Homeobox gene interactions become exponentially complex as the multidimensional nature of gene regulatory networks is explored. However, it has given rise to an entirely new perspective on developmental biology and molecular genomics.

Oct 1, 1997 · Homeobox genes are master developmental control genes that act at the top of genetic hierarchies regulating aspects of morphogenesis and cell differentiation in animals. These genes contain a...

Homeobox refers to a conserved DNA sequence responsible for encoding a 60-amino acid protein motif called the homeodomain. This domain functions as a helix-turn-helix DNA-binding motif, allowing homeobox genes to act as transcription factors in various developmental processes across different organisms.

Dec 20, 2023 · Homeobox genes are responsible for determining the pattern of development in various organisms, from flies to humans. They are involved in the formation of body segments, the differentiation of specific cell types, and the establishment of overall body plan.

Jul 2, 2019 · Homeobox is a DNA sequence that occurs in homeotic genes. It was first discovered in Drosophila. Generally, it is 180 base pairs long. Also, it occurs within homeotic genes of all eukaryotes, including animals, plants, and fungi. On the other hand, homeobox synthesizes a protein domain called homeodomain, which is 60 amino acids long.

Nov 10, 2005 · NK homeobox genes are evolutionary relatives of both Hox and ParaHox genes, and are found in clusters in some lineages. Comparative genomics studies strongly indicate that Hox, ParaHox and NK...

Oct 26, 2007 · We describe 300 human homeobox loci, which we divide into 235 probable functional genes and 65 probable pseudogenes. These totals include 3 genes with partial homeoboxes and 13 pseudogenes that lack homeoboxes but are …

Homeobox-containing genes encode DNA-binding proteins that regulate gene expression and control various aspects of morphogenesis and cell differentiation.