The HOIL-1L ligase modulates immune signalling and cell …
May 11, 2020 · We found that HOIL-1L RBR plays a crucial role in regulating LUBAC. HOIL-1L RBR conjugates monoubiquitin onto all LUBAC subunits, followed by HOIP-mediated …
HOIL and water: the two faces of HOIL-1 deficiency - Nature
Oct 28, 2012 · In this issue of Nature Immunology, Boisson et al. describe a previously unknown disease caused by mutations in RBCK1 (called 'HOIL1' here), which encodes HOIL-1, a …
Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L ...
Oct 13, 2023 · Heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L) serves as a unique E3 ligase to catalyze the mono-ubiquitination of relevant protein or sugar substrates and plays vital roles in …
The HOIL-1L ligase modulates immune signalling and cell death …
We found that HOIL-1L RBR plays a crucial role in regulating LUBAC. HOIL-1L RBR conjugates monoubiquitin onto all LUBAC subunits, followed by HOIP-mediated conjugation of linear …
Structural basis for ubiquitylation by HOIL-1 - PMC - PubMed …
We show that HOIL-1 activity requires linear tetra-Ub binding which enables HOIL-1 to mono-ubiquitylate linear Ub chains and polysaccharides. Furthermore, we describe the crystal …
HOIL-1, an atypical E3 ligase that controls MyD88 signalling by …
Here we review recent developments in our understanding of this network, focusing on the unexpected discovery that the E3 ligase HOIL-1 initiates the formation of hybrid ubiquitin …
HOIL: Molecular Composition, Deficiency, and Immune Impact
Feb 7, 2025 · HOIL, or heme-oxidized IRP2 ubiquitin ligase 1, is a crucial component of the immune system. Understanding its molecular composition and function provides insights into …
HOIL1 Is Essential for the Induction of Type I and III ... - PubMed
Nov 12, 2018 · The linear ubiquitin chain assembly complex (LUBAC), composed of heme-oxidized IRP2 ubiquitin ligase 1 (HOIL1), HOIL1-interacting protein (HOIP), and SHANK …
35 Facts About HOIL-1L Mutation
Dec 5, 2024 · The HOIL-1L mutation is a genetic alteration affecting the HOIL-1L gene, which plays a crucial role in the immune system. This mutation can lead to various health issues, …
Here, we demonstrate that the HOIL-1L NZF domain has important regulatory functions Hoil-1lT201A;R208A/T201A;R208A in inflammation and immune responses in mice.