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The Molecular Mechanisms Regulating the KEAP1 …
Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by targeting it for ubiquitination and proteasome-dependent degradation.
PubMed
https://pubmed.ncbi.nlm.nih.gov
Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in …
Mar 15, 2017 · Heme oxygenase (HO)-1 in adipocytes protects against obesity and adipose dysfunction. In this study, we report the identification of butein, a flavonoid chalcone, as a …
- Author: Zheng Wang, Sun-O Ka, Youngyi Lee, Byung-Hyun Park, Eun Ju Bae
- Publish Year: 2017
Nature
https://www.nature.com › articles
A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and
Jul 5, 2021 · In primary murine and human osteoblasts, iKeap1 robustly activated Nrf2 signaling at micromole concentrations. iKeap1 disrupted Keap1-Nrf2 association, causing Nrf2 protein …
- Author: Yue-huan Zheng, Jian-jun Yang, Pei-jun Tang, Yuan Zhu, Zhe Chen, Chang She, Gang Chen, Peng Cao, Xia...
- Publish Year: 2021
Studies of Ho-1 Keap
PubMed
Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice
Adipose tissue inflammation and oxidative stress are key components in the development of obesity and insulin resistance. Heme oxygenase (HO)-1 in adipocytes protects against obesity and adipose dysfunction. In this study, we report the identification of butein, a flavonoid chalcone, as a novel indu...
Author: Zheng Wang
Published: 2017/03/15
Keywords: Adipose hy…
ScienceDirect
Modulation of keap-1/Nrf2/HO-1 and NF-ĸb/caspase-3 signaling pathways by dihydromyricetin ameliorates sodium valproate-induced liver injury
Nuclear factor erythroid factor 2 (Nrf2) is the key regulatory of the antioxidant response elements. Also, Nrf2 interacts with nuclear factor kappa B (NF-ĸB) to inhibit subsequent inflammatory cascade. Activation of Nrf2 signaling ameliorates drug-induced liver injury. Sodium valproate (SVP) is an a...
Published: 2024/08/01
Cited By: 0
Keywords: Dihydromyr…
PubMed
Keap1/Nrf2/HO-1 signaling pathway contributes to p-chlorodiphenyl diselenide antidepressant-like action in diabetic mice
Rationale: The association between depression and diabetes has been recognized for many years, but the nature of this relationship remains uncertain. Objectives: This study investigated the antidepressant-like effect of (p-ClPhSe)2 on mice made diabetic by streptozotocin (STZ) and the contributi...
Author: Vanessa A Zb…
Published: 2020/2
Keywords: The associ…
National Center for Biotechnology Information
High KEAP1, NRF2 and Low HO-1 Serum Levels in Children with Autism
Introduction: The purpose of our study was to investigate heme oxygenase-1 (HO-1), nuclear factor erythroid-2-related factor 2 (NRF2), and kelch-like ECH-associated protein 1 (KEAP1) levels in children with autism spectrum disorder (ASD) and to reveal their association with the severity of autism. ...
Author: Hamza AYAY…
Published: 2020/12
Publication: Noro Psiki…
ScienceDirect
Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease
Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription factor, has been documented to induce a defense mechanism against oxidative stress damage, and growing evidence considers this signaling pathway a key pharmacological target for the treatment of liver dise...
Published: 2021/11/01
Keywords: Nrf2; Nrf2 a…
DOI: 10.1016/j.phymed…
PubMed
Modulation of keap-1/Nrf2/HO-1 and NF-ĸb/caspase-3 signaling pathways by dihydromyricetin ameliorates sodium valproate-induced liver injury
Nuclear factor erythroid factor 2 (Nrf2) is the key regulatory of the antioxidant response elements. Also, Nrf2 interacts with nuclear factor kappa B (NF-ĸB) to inhibit subsequent inflammatory cascade. Activation of Nrf2 signaling ameliorates drug-induced liver injury. Sodium valproate (SVP) is an a...
Author: Doaa Emad
Published: 2024 Jul
Keywords: Dihydromyr…
ScienceDirect
Review Article The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease?
Aging entails the deterioration of the body's organs, including overall damages at both the genetic and cellular levels. The prevalence of age-related ocular disease such as macular degeneration, dry eye diseases, glaucoma and cataracts is increasing as the world's population ages, imposing a consid...
Published: 2024/06/01
Cited By: 0
Keywords: Aging; Deg…
PubMed
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by targeting it for ubiquitination and proteasome-depen...
Author: Liam Baird
Published: 2020/06/15
Keywords: E3 ubiquiti…
PubMed
Relationship Between Oxidative Stress, Tau Level and Antioxidant Mechanisms of the KEAP-1/NRF-2/HO-1 in Children with Hydrocephalus
Background: Hydrocephalus is a complex neurologic disorder that has a widespread impact on the central nervous system and a multifactor disease which affects the CSF dynamics and causes severe neurological impairments in children. The pathophysiology of hydrocephalus is not fully understood. However...
Author: Ahmet Guzelci…
Published: 2021
Keywords: Hydroceph…
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Role of Nrf2/HO-1 system in development, oxidative stress …
Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [5], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. Under normal conditions, …
ScienceDirect
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Modulation of keap-1/Nrf2/HO-1 and NF-ĸb/caspase-3 signaling …
Aug 1, 2024 · Given that Nrf2's inhibitor, Keap-1, regulated Nrf2 activity at the level of post-translational degradation, overexpression of Keap-1 reduced Nrf2 levels and eliminated Nrf2 …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Nrf2/Keap1/ARE signaling: Towards specific regulation
Increase of intracellular heme level inhibits Bach1 negative regulation of Nrf2, allowing Nrf2 to activate target genes, including heme oxygenase-1 (HO-1), the key enzymes, regulating heme catabolism .
People also ask
What does Keap1 do?
Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton , serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. Under normal conditions, Keap1 promotes ubiquitination and eventual degradation of Nrf2.
Role of Nrf2/HO-1 system in development, oxidative stress response and
pmc.ncbi.nlm.nih.gov
What is nuclear Keap1 import?
Nuclear Keap1 import is Nrf2-independent and is mediated through importin α7 . Similar to Nrf2, Keap1 contains NES, ensuring mechanism to terminate Nrf2 activity through its export to cytoplasm after recovery of cellular redox homeostasis , .
Nrf2/Keap1/ARE signaling: Towards specific regulation - PMC
pmc.ncbi.nlm.nih.gov
What is Class V Keap1?
Class V consists of compounds which inactivate KEAP1 but function independently of Cys151, Cys226, Cys273, Cys288, Cys613, Cys622, and Cys624. The fact that class V compounds, including prostaglandin A 2 (PGA 2), cannot stabilize NRF2 in an 11-cysteine mutant of KEAP1 suggests that they function through an as-yet-unidentified sensor.
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
pmc.ncbi.nlm.nih.gov
What is Keap1 structure?
106. Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M. 2010. Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
pmc.ncbi.nlm.nih.gov
How does Keap1 bind to Nrf2?
Keap1 will promote Nrf2 protein degradation through the ubiquitin-proteasome system by Cullin 3 (Cul3) [13, 16]. Activated Nrf2, however, will separate from Keap1 [11, 12, 13]. Stabilized Nrf2 protein then translates to cell nuclei and binds to anti-oxidant response elements (ARE) as well as small MAF transcription factors.
A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ... - Nature
nature.com
What does HO-1 stand for?
Keywords: Heme oxygenase-1 (HO-1), Kelch-like ECH-associated protein 1 (Keap1), Nuclear factor erythroid 2-related factor 2 (Nrf2), Oxidative stress, Reactive oxygen species (ROS) Living organisms are frequently exposed to oxidative stress and toxic insults, like radiation, UV light, air pollution, toxins and others.
Role of Nrf2/HO-1 system in development, oxidative stress response and
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Keap1/Nrf2/HO-1 signaling pathway contributes to p ... - PubMed
This study demonstrates the contribution of cerebral cortical Keap1/Nrf2/HO-1 pathway in the (p-ClPhSe) 2 antidepressant-like action in diabetic mice.
PubMed
https://pubmed.ncbi.nlm.nih.gov
Modulation of keap-1/Nrf2/HO-1 and NF-ĸb/caspase-3 signaling …
In this study, coadministration of Dihydromyricetin (DHM), a natural flavonoid, with SVP to rats upregulated gene expression of Nrf2 and its downstream gene, heme oxygenase 1 (HO-1), …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
High KEAP1, NRF2 and Low HO-1 Serum Levels in Children with …
Sep 21, 2020 · The purpose of our study was to investigate heme oxygenase-1 (HO-1), nuclear factor erythroid-2-related factor 2 (NRF2), and kelch-like ECH-associated protein 1 (KEAP1) …
ScienceDirect
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Targeting Nrf2/Keap1 signaling pathway by bioactive natural …
Nov 1, 2021 · Under a stress environment, Nrf2 binds to the antioxidant response elements (AREs) and activates downstream targets such as Heme Oxygenase-1 (HO-1), Catalase …
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The Molecular Mechanisms Regulating the KEAP1 …

Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in …

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and

Role of Nrf2/HO-1 system in development, oxidative stress …

Modulation of keap-1/Nrf2/HO-1 and NF-ĸb/caspase-3 signaling …

Nrf2/Keap1/ARE signaling: Towards specific regulation

Role of Nrf2/HO-1 system in development, oxidative stress response and

Nrf2/Keap1/ARE signaling: Towards specific regulation - PMC

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ... - Nature

Role of Nrf2/HO-1 system in development, oxidative stress response and

Keap1/Nrf2/HO-1 signaling pathway contributes to p ... - PubMed

Modulation of keap-1/Nrf2/HO-1 and NF-ĸb/caspase-3 signaling …

High KEAP1, NRF2 and Low HO-1 Serum Levels in Children with …

Targeting Nrf2/Keap1 signaling pathway by bioactive natural …