HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.

DR-18, a variant of the human cytokine interleukin-18, binds to IL-18 binding protein (IL-18BP) and overcomes the inhibitory effect of the IL-18BP on IL-18, which may boost the body's immune system and may interfere with the ability of tumor cells to grow and spread.

HLA-DR is an αβ heterodimer, cell surface receptor, each subunit of which contains two extracellular domains, a membrane-spanning domain and a cytoplasmic tail. Both α and β chains are anchored in the membrane.

HLA-DR antigen specificities (i.e., DR1 to DR18) are determined by the polymorphic DRβ1 chains encoded by DRB1 alleles. HLA haplotypes of certain DRB1 alleles contain specifically linked DRB3 , DRB4 , or DRB5 locus.

Nov 5, 2024 · Using murine models, we found DR-18 overcomes IL18BP mediated immune suppression and reverses CD8+ T cell exhaustion by increasing NK cell activity. As a result, DR18 stimulates IFNγ-mediated GVL effects without exacerbating graft-vs-host disease (Minnie et al, Sci Immunol. 2022, PMID: 36240285).

HLA--DR1 through HLA-DR18. The products of A and B3 genes express HLA-DR52, those of A and B4 genes express DR53 and those of A and B5 genes express DR51.[10] Nomenclature Progress from serology to molecular technique has led to nomenclature changes also. For example, HLA-DR3 is the broadest description of the antigen.

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene- allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

For example, HLA-DR3 is a broad antigen that has been subdivided into HLA-DR17 and HLA-DR18 with improved HLA typing methods. Depending on the year of HLA typing and transplantation, a patient may have only information on broad HLA antigens, without information on the corresponding split antigens.

DR-18, a variant of the human cytokine interleukin-18, binds to IL-18 binding probein (IL-18BP) and overcomes the inhibitory effect of the IL-18BP on IL-18, which may boost the body's immune system and may interfere with the ability of tumor cells to grow and spread.

HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.