HLA-B40 (B40) is an HLA - B serotype. B40 is composed of the B60 and B61 split antigen serotypes. [1] B*40:05 is poorly recognized by B40, B60, or B61.

HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex.

These data suggest that HLA-B40 is a marker of increased susceptibility to lung disease in patients with rheumatoid arthritis. We have compared the frequency of HLA antigens in groups of patients with rheumatoid arthritis (RA) who had pulmonary manifestations, other extra-articular features or articular disease alone.

Dec 6, 2014 · To address these issues, we conducted a mass screening of 6pLOH (+) leukocytes in newly diagnosed AA patients using an assay that allows us to detect 6pLOH (+) cells within one day, and reanalyzed haplotypes that are likely to be lost.

Objective: To determine gene frequencies of HLA-B alleles in Mexicans (individuals with Native American genetic background admixed with European descent) with ALL and AML. Methods: We compared the HLA-B alleles in 213 patients with ALL and 85 patients with AML to those present in 731 umbilical cord blood (UCB) samples as a control group; this ...

HLA-B40 was the second most common HLA-B subtype in all of the AS patients besides HLA-B27. Then the genotype HLA-B27:04/B * 40:01 can improve diagnostic accuracy, and patients with HLA-B * 27:04/B * 46:01 had a high risk of arthritis and enthesitis.

HLA-B40 Antigen / genetics* Humans Incidence Male Odds Ratio Reference Values Risk Assessment Spain / epidemiology Spondylitis, Ankylosing / diagnosis ...

By combining affinity purification with high-resolution mass spectrometry, we identified more than 2000 unique ligands bound to HLA-B40. Sequence analysis revealed two major anchor motifs: aspartic or glutamic acid at peptide position 2 (P2) and methionine, phenylalanine, or aliphatic residues at the C terminus.

In RA, there is an association between obliterative bronchiolitis (OB) and the expression of histocompatibility antigens HLA-B40 and DR1, which implicates a genetic risk factor.

Jun 1, 2016 · However, the HLA-B*40:01 allele was significantly increased in B*27-positive patients with AS compared with B*27–positive controls (P BONF < 0.001, OR 23.36, 95% CI 3.04–179.42).