HLA-B22 (B22) is an HLA - B serotype. B22 is a broad antigen serotype that recognizes the B54, B55, and B56 split antigen serotypes. [1]

Human leukocyte antigen (HLA) is an important component of the viral antigen presentation pathway, and it plays an essential role in conferring differential viral susceptibility and severity of diseases. HLA alleles have been involved in the immune response to …

Sep 15, 2003 · The human leukocyte antigen (HLA)-B22 serogroup--which consists of the alleles B*54, B*55, and B*56--has been associated with rapidly progressive disease in white patients with human immunodeficiency virus (HIV) infection.

Here, by investigating the HLA-B genotypes in 190 unrelated Chinese patients with confirmed COVID-19, we identified a significant positive association between the B22 serotype and SARS-CoV-2 infection (p = 0.002, Bonferroni-corrected p = 0.032).

Dec 1, 2020 · HLA class I molecules play a crucial role in directing anti‐viral immune responses and their genetic heterogeneity thus dictates clinical reactions and outcomes among individuals. Here, we showed that the HLA‐B22 serotype is a potential risk marker for SARS‐CoV‐2 infection.

Along with previous data, B22 appears to be a very diverse group in the Korean population consisting of at least seven different alleles. B*5401, B*5502, and B*5601 are the most frequent alleles. B*5507, B*5501, B*5504, and B*5604 appear at lower frequencies.

Aug 1, 1999 · In this study, we investigated the diversity of the B22 group and the association of each B22 allele with adjacent HLA-C and -DRB1 loci in the Korean population, using PCR-SSOP and DNA sequencing analyses.

Aug 4, 2016 · These results suggest that a hyporesponsiveness of NK cells due to poor education plus missing of activating KIRs, as well as by CTLs due to nonresponsive HLA-B22, play an important role in VKH pathogenesis following viral infections in genetically susceptible individuals, such as HLA-DR4 carriers.

Nov 24, 2021 · Univariate analysis revealed higher HLA‐A10, HLA‐B*13, HLA‐B22, and HLA‐B*55 allele frequencies in patients infected with COVID‐19 compared to the control group. HLA‐A10 is a group named after serological typing.

HLA system is critical in mediating anti-viral immunity and recent. studies have suggested preferential involvement of HLA-B in COVID-19 sus-ceptibility. Here, by investigating the HLA-B genotypes in 190 unrelated Chi-nese patients with confirmed COVID-19, we identified a …