HLA-B15 (B15) is an HLA-B serotype. The serotype identifies the B*15 gene-allele protein products of HLA-B. [1] B15 is a broad antigen and can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77.

Mar 20, 2025 · Human leukocyte antigen B15 (HLA-B15) is a key component of the immune system, presenting antigens to T cells. Variations in this gene influence immune responses, affecting susceptibility to infections and autoimmune conditions. Understanding HLA-B15’s role provides insights into disease mechanisms and potential therapeutic approaches.

HLA-B15 embraces a multiplicity of antigenic specificities which vary in their distribution amongst human populations. To correlate B15 molecular structure with the serological picture we have sequenced alleles encoding the various subspecificities of the B15 antigen: B62, B63, B75, B76 and B77, and …

Human leucocyte antigen (HLA) HLA-B15 has been associated with spondyloarthritis (SpA) and oligoarthritis in different populations. This study clearly establishes this association through a detailed analysis of the clinical and radiological aspects in …

HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex.

Identification of specific amino acid motifs for each B15 serological subtype. HLA-B15 represents one of the largest broad antigen groups with different serological subtypes, containing B62, B63, B75, B76 and B77 specificities and is also associated with B71 and B72 (belonging to the B70 broad antigen) (Fig. 1b). The alignment of the 105 HLA-B ...

Jul 19, 2023 · The human leukocyte antigen allele HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection due to pre-existing T cell immunity.

Aug 4, 2023 · By assessing peripheral blood mononuclear cells in volunteers from the National Marrow Donor Program, the group confirmed the initial hypothesis that asymptomatic individuals carrying the HLA-B*15:01 allele have pre-existing T-cell immunity due to cross-reactivity with seasonal coronavirus peptides. “The study uncovers a degree of natural ...

HLA-B antigens are serologically classified into 26 groups (Mori et al., 1997): HLA-B48, -B60, -B61, and -B81 are serologically identical as a group to HLA-B40; and HLA-B62, -B63, -B70, -B71, -B72, -B75, -B76, and -B77 serologically belong to a group including HLA-B15 (or HLA-B62).

The HLA-B15 typing by serological approaches defined the serological subgroups (or splits) B62, B63, B75, B76, B77 and B70 (B71 and B72). The scarcity of sera with specific anti-HLA antibodies makes the serological typing method difficult to discriminate a high variety of HLA antigens, especially be …