HLA-B12 (B12) is an HLA - B serotype. B12 is a broad antigen serotype that recognizes the B44 and B45 split antigen serotypes. [1]

HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]

HLA-B12 is a specific subgroup of the HLA-B antigen that has been found to be significantly increased in patients with Stevens-Johnson Syndrome (SJS) with ocular involvement, particularly in Caucasian populations.

Dec 9, 2022 · Platelet transfusion therapy for alloimmunized patients: selective mismatching for HLA B12, an antigen with variable expression on platelets.

Oct 1, 2020 · Human leukocyte antigen (HLA) alloimmunization is a major cause of immune platelet refractoriness, and its rate can be significantly reduced by implementation of leukoreduction. Despite promising preclinical results, pathogen reduction does not reduce HLA alloimmunization.

HLA-B12 was found to be expressed on platelets from each of 25 heterozygous HLA-B12-positive donors in amounts varying about 35-fold from weakest to strongest. Expression of B12 on platelets was enhanced in the presence of the first locus antigen A11, but decreased in the presence of A2, A3, and Aw28.

Among 27 patients with anaemia associated with endocrine disease there was an increased frequency of HLA-B8, B18, and BW15. The remaining 100 patients, who did not have endocrine disease, showed increased frequencies of HLA-B7 and B12.

Four B12 subtypes are described, tentatively designated as B12-related CML targets. Identification of HLA-B-related CML targets represent CML "typing" of HLA-antigen differences that were not detected serologically.

Fifteen HLA-B specificities were found to comprise the B12 cross-reactive group and its related cross-reactions, with bidirectional cross-reactivity occurring between Bw44, Bw45, Bw49 and Bw50 (unidirectional between Bw44 and Bw50).

Expression of the antigen HLA-B12 on platelets, on lymphocytes and in serum of normal subjects was studied using several quantitative techniques. HLA-B12 was found to be expressed on platelets from...