E2F activity is modulated by pRb and CDK2/4/6 as well as CDK kinase inhibitors, and E2F activation is required for G1/S transition. The ectopic expression of LATS2 hinders G1/S progression, and LATS2 depletion inhibits pRb-induced senescence [ 130 , 183 ].

Some of the cell cycle functions of the Hippo pathway may also be linked to interactions with transcriptional complexes such as the DREAM complex (dimerization partner, RB-like, E2F and multi-vulval class B) and related complexes involved at various steps of cell cycle progression.

We propose that under normal conditions E2Fs do not substantially contribute to the proliferative potential of a cell. Deregulated expression or activity of most members of the E2F family has...

Oct 3, 2008 · Consistently, Hippo pathway mutant cells had elevated E2F activity and induced dE2F1 expression at a point when wild-type cells normally exit the cell cycle. Thus, we uncovered a critical requirement for the dE2F family during inappropriate proliferation of …

Among E2F genes, the E2F3 and E2F7 loci can undergo two alternative splicing events to encode four protein isoforms: E2F3a, E2F3b, E2F7a, and E2F7b (29–31). The E2F family can be broadly divided into two categories, typical E2Fs (E2F1-6) and atypical E2Fs (E2F7-8), based on their unique structural characteristics (32, 33).

Mar 7, 2013 · In this Review, we appraise the evidence for the Hippo pathway as a cancer signalling network, and discuss cancer-relevant biological functions, potential mechanisms by which Hippo pathway...

Feb 5, 2022 · E2F transcription factors (E2Fs) are a group of genes that codify a family of transcription factors (TFs) which consist of eight family members in the mammalian cells, which play a critical role in regulating the expression of many genes required for cell cycle progression, DNA repair, and apoptosis. 1, 2 The members of this family can be ...

Feb 14, 2016 · Some of the cell-cycle functions of the Hippo pathway may also be linked to interactions with transcriptional complexes such as the DREAM complex (dimerization partner, RB-like, E2F and multi-vulval class B; ref. 136) and related complexes involved at various steps of cell-cycle progression.

In this study, we found that Drosophila E2F1 and RBF regulate apoptosis via interactions with Hippo signaling, and thereby affect organ size and tissue homeostasis.

Jan 1, 2013 · The Hippo pathway regulates cell growth and cell cycle-dependent ­processes, including mitosis, cell cycle checkpoints, mitotic checkpoints, and DNA damage response (DDR) checkpoints, thereby preventing the accumulation of abnormal cells with aneuploidy and...