Asoxime chloride, or more commonly HI-6, is a Hagedorn oxime used in the treatment of organophosphate poisoning. [1]

An HI-6 salt derivative (HI-6 dimethanesulphonate) with increased water solubility, for potential use in an autoinjector, is currently under development and has been shown to have the same …

May 9, 2019 · After half a century of extensive military medical research and development for the Bundeswehr HI 6 - DMS is a relatively new development in the field of oximes, representing a …

In the work presented here, oximes (HI-6, obidoxime, trimedoxime, Figure 1) that are structurally and therapeutically well-defined were used as standards to help correlate the biological …

Jan 1, 2024 · HI-6 DMS is the proposed oxime replacement for P2S in the triple therapy nerve agent medical countermeasure and it is, therefore, necessary to provide evidence to …

The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by …

HI-6 rapidly reactivated human blood acetylcholinesterase inhibited by diethoxy organophosphorus compounds, while the dimethoxy-inhibited enzyme was mainly resistant to …

The bispyridinium oxime HI-6 DMS is in development as an improved therapy for the treatment of patients exposed to organophosphorus nerve agents. The aim of the work described in this …

Jul 29, 2011 · HI-6 has been demonstrated to be generally a superior reactivator of nerve agent inhibited enzyme, particularly with human and non-human primate derived enzyme, and has …

In this study, PEGylated liposomes loading HI-6 were prepared and evaluated in vitro and in vivo. For PEG-LP-HI-6, the optimal formulation’s loading efficiency and encapsulation efficiency …