hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as K v 11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply …

Jun 1, 2020 · We provide in this concise review clear guidelines, based on described examples, illustrating successful optimization process to avoid hERG interactions as cases studies and to …

The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr), which is important for cardiac …

Nov 24, 2014 · The human ether-à-go-go related gene (hERG) potassium channel is an obligatory anti-target for drug development on account of its essential role in cardiac repolarization and …

Jun 1, 2020 · Early detection of hERG toxicity based on several practical tools is reviewed. hERG structure analysis offers new possibilities to predict detrimental binding. A guide for scientists …

Jan 24, 2020 · The human voltage-sensitive K + channel hERG plays a fundamental role in cardiac action potential repolarization, effectively controlling the QT interval of the …

Jan 29, 2021 · The human ether-a-go-go-related gene K + channel (hERG) is a voltage-activated channel known for its role in the repolarization of cardiac cells (1, 2). A hallmark of hERG …

hERG is a tetrameric potassium channel formed by four subunits that are encoded by Kv11.1 (hERG). Voltage-dependent inactivation is caused by conformational changes in the outer …

HERG (human ether-a-go-go-related channel) is a voltage-dependent K+ channel that has unique biophysical properties. HERG activates upon depolarization but inactivates rapidly, and …

Feb 25, 2020 · The human ether-a-go-go-related gene1 (hERG) ion channel has been the subject of fascination since it was identified as a target of long QT syndrome more than 20 years ago. …