The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding
Nov 16, 2021 · The HER2 receptor and its MUC4 mucin partner form an oncogenic complex via an extracellular region of MUC4 encompassing three EGF domains that promotes tumor …
MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein …
Apr 1, 2008 · We provide experimental evidence for the interaction of MUC4 and HER2 in pancreatic cancer cells. Furthermore, we show that the short-interfering RNA (siRNA)–induced …
The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding …
In this study, we specified the binding mode of MUC4 EGF domains with HER2 and demonstrate their “growth factor-like” biological activities in PC cells leading to stimulation of several …
MUC4 stabilizes HER2 expression and maintains the cancer stem …
The exogenous MUC4 expression in ovarian cancer cells showed an increase in HER2 expression and colocalization, suggesting that MUC4 is involved in the stabilization of HER2 …
Structure, evolution, and biology of the MUC4 mucin - PMC
MUC4 colocalizes and physically interacts with the receptor tyrosine kinase HER2 in pancreatic cancer cells (unpublished data). HER2 is a member of the epidermal growth factor receptor …
MUC4 activates HER2 signalling and enhances the motility of …
Aug 5, 2008 · Reciprocal co-immunoprecipitation revealed an interaction of MUC4 with HER2. Further, the MUC4-overexpressing SKOV3 cells exhibited an increase in the phosphorylation …
MUC4 mucin interacts with and stabilizes the HER2 oncoprotein
Apr 1, 2008 · In the present study, we have shown the interaction of human MUC4 with the receptor tyrosine kinase HER2 in pancreatic adenocarcinoma cells by reciprocal …
MUC4 mucin- a therapeutic target for pancreatic ductal …
MUC4 has been shown to mediate resistance to gemcitabine treatment, which is a first-line therapy for the advanced PDAC . MUC4 reduced cytochrome c release in a HER2-dependent …
MUC4 induces activation of HER2 signaling resulting in an …
May 1, 2008 · The overexpression of MUC4 induces the expression and activation of HER2 and its downstream signaling, such as of FAK, Akt and ERK pathways. Furthermore, the MUC4 …
MUC4 activates HER2 signalling and enhances the motility of …
Jul 29, 2008 · Reciprocal co-immunoprecipitation revealed an interaction of MUC4 with HER2. Further, the MUC4-overexpressing SKOV3 cells exhibited an increase in the phosphorylation …