Helicases are motor proteins that move directionally along a nucleic double helix, separating the two hybridized nucleic acid strands (hence helic- + -ase), via the energy gained from ATP hydrolysis. There are many helicases, representing the great variety of processes in which strand separation must be catalyzed.

Oct 24, 2024 · DNA helicases are ubiquitous enzymes found in all domains of life and associated with nucleic acid metabolisms such as DNA replication, transcription, translation, DNA repair, recombination, ribosome biogenesis, and decay. DNA helicase was …

Because of their essential function, helicases are ubiquitous and evolutionary conserved proteins. This chapter briefly highlights helicase structure and activities and provides examples of the helicases involved in nucleic acid metabolism.

Helicases couple the chemical energy of NTP 2 binding and hydrolysis to separate the complementary strands of double-stranded nucleic acids, remove nucleic acid-associated proteins, or catalyze homologous DNA recombination. Although helicases display these activities in isolation, most work efficiently as part of a larger protein complex.

Oct 17, 2024 · Helicases are enzymes essential for maintaining genetic information integrity. These molecular motors unwind DNA and RNA strands, facilitating replication, repair, transcription, and translation. Their function is indispensable to cellular life, ensuring accurate duplication and expression of genetic material.

DNA helicases not only play essential roles in replication, DNA repair, and recombination, but they also influence gene expression and chromosome structure and act to resolve dynamic DNA structures that pose a source of genomic instability.

Helicases are a class of enzymes which are motor proteins using energy derived from ATP hydrolysis to move directionally along a nucliec acid phosphodiester backbone (such as DNA, RNA and DNA-RNA hybrids) and separate two annealed nucleic acid strands.

In this review we cover the historical background of DNA helicases, helicase assays, biochemical properties, prokaryotic and eukaryotic DNA helicases including Mcm proteins and the RecQ family of helicases.

Jul 20, 2023 · RNA helicases are enzymes that use nucleoside triphosphates (NTPs) to bind or remodel RNA, ribonucleoprotein (RNP) complexes or both 1. RNA helicases are present in bacteria, archaea and...

Oct 15, 2024 · Explore the crucial roles of DNA helicases in genetic processes and their impact on health and disease. DNA helicases are essential enzymes that maintain genome stability by unwinding the DNA double helix, facilitating processes like replication and repair.