CDK4 protein is degraded by anaphase-promoting …
Here, we show that CDK4 protein is degraded by anaphase-promoting complex/cyclosome (APC/C) during metaphase-anaphase transition in HeLa cells, whereas its main regulator, …
CDK4 protein is degraded by anaphase-promoting complex
Jun 16, 2017 · Here, we show that CDK4 protein is degraded by anaphase-promoting complex/cyclosome (APC/C) during metaphase-anaphase transition in HeLa cells, whereas its …
A Cyclin D-Cdk4 Activity Required for G2 Phase Cell
May 14, 1999 · Here we report that in UV-irradiated HeLa and A2058 cells, p16 bound Cdk4 and Cdk6 complexes with increased avidity and inhibited a cyclin D3-Cdk4 complex normally …
Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell ... - Cell …
Apr 14, 2020 · Pharmacological inhibition of Cdk4/6 leads to a rapid, TSC2-dependent reduction of mTORC1 activity in multiple human and mouse cell lines, including breast cancer cells. By …
CDK4 is degraded by APC/C in mitosis and reaccumulates in early …
Apr 26, 2017 · Here, we show that CDK4 protein is degraded by APC/C during metaphase-anaphase (M-A) transition in HeLa cells, whereas its main regulator cyclin D1 remains intact …
Here, we show that CDK4 protein is degraded by anaphase-promoting complex/cyclosome (APC/C) during metaphase-anaphase transition in HeLa cells, whereas its main regulator, …
Cyclin-dependent kinase 4 inhibits the translational repressor 4E …
We recently reported a site-selective chemoproteomic method for uncovering kinase-substrate interactions, and using this approach, we discovered the cyclin-dependent kinase (CDK)4 as a …
CDK4 protein is degraded by anaphase-promoting …
CDK4 regulates G1/S phase transition in the mammalian cell cycle by phosphorylating retinoblastoma family proteins. However, the mechanism underlying the regulation of CDK4 …
CDK4: a master regulator of the cell cycle and its role in cancer
This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 …
CDK4 protein is degraded by anaphase-promoting complex/cyclosome in ...
Dec 19, 2016 · Here, we show that CDK4 protein is degraded by anaphase-promoting complex/cyclosome (APC/C) during metaphase-anaphase transition in HeLa cells, whereas its …
- Some results have been removed