The discography of the American rock band Heart consists of 15 studio albums, nine live albums, nine compilation albums, 64 singles and 35 music videos. The group, led by Ann and Nancy Wilson, have sold about 35 million records worldwide. [1]

In the present study, we investigated the direct effects of LPS on the cardiac contractility of isolated ventricular myocytes using a Langendorff apparatus. Changes in the relevant signalling pathways were also characterised in H9c2 cells exposed to LPS.

Oct 17, 2024 · Heart mass indexed to body mass in the LPS group was significantly higher compared to the control group (P = 0.002). The internal diameter of the LV chamber during both diastole (P = 0.04) and...

Mar 16, 2001 · Fluorescently labeled LPS was used to treat primary cardiomyocyte cultures, perfused heart preparations, and the RAW264.7 macrophage cell line. Using confocal microscopy and spectrofluorometry, we found that LPS was rapidly internalized in cardiomyocyte cultures and Langendorff-perfused hearts.

Jun 7, 2017 · To investigate the effects of LPS on the electrophysiological properties of cardiomyocytes, hiPSC-CMs were treated by 0.1 and 1 µg/ml LPS for 48 hours and then the membrane potentials and ...

H 2 protects against LPS-induced cardiac dysfunction via suppressing the excessive production of pro-inflammatory cytokines in the parenchymal cells of the heart by blocking TLR4-MAPKs/NF-κB signaling.

One day after LPS injection, heart histopathology, cardiac marker enzymes and cardiac fibrosis related genes were determined to evaluate the cardioprotective effects of rutin. In addition, oxidative parameters and inflammatory cytokines were tested to …

Sep 24, 2024 · LPS pretreatment confers cardiac protection against ISO-induced injury through TLR4 mediated type 1 and 2 interferon signaling, consistent with trained innate immune tolerance.

Jan 25, 2022 · Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation of Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-α production and dysfunction by...

Recently we reported that BN rats were more resistant to lipopolysaccharide (LPS)-induced myocardial dysfunction than SS rats. This differential sensitivity was exemplified by reduced production of proinflammatory cytokines and diminished NFκB pathway activation.